Table 1 |
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|
Functional annotation of defined patient subgroups. |
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|
M |
N1 |
N2 |
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|
|
||||||||
|
category |
n |
p |
category |
n |
p |
category |
n |
p |
|
|
||||||||
|
DAVID IDs |
||||||||
|
|
||||||||
|
258 |
383 |
238 |
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|
|
||||||||
|
Biological processes |
||||||||
|
|
||||||||
|
230 |
344 |
203 |
||||||
|
DNA replication |
13 |
5E-3 |
endodome transport |
7 |
1E-3 |
development |
38 |
9E-3 |
|
taxis |
9 |
7E-3 |
vacuole organization and biogenesis |
7 |
9E-3 |
reactive oxygen species metabolism |
6 |
1E-2 |
|
carbohydrate metabolism |
25 |
9E-3 |
response to chemical stimuli |
23 |
1E-2 |
response to oxidatïve stress |
5 |
3E-2 |
|
negative regulation of biological processes |
26 |
1E-2 |
regulation of enzyme activity |
20 |
3E-2 |
dephosphorylation |
6 |
2E-2 |
|
nucleic acid metabolism |
69 |
2E-2 |
vesicle mediated transport |
18 |
3E-2 |
intracellular protein transport |
18 |
3E-2 |
|
|
||||||||
|
Molecular function |
||||||||
|
|
||||||||
|
238 |
347 |
211 |
||||||
|
DNA binding |
39 |
2E-2 |
protein dimerization activity |
14 |
2E-2 |
protein domain specific binding |
6 |
3E-2 |
|
protein dimerization activity |
10 |
5E-2 |
hydrolase activity on glycosyl bonds |
12 |
5E-2 |
GTPase activity |
7 |
5E-2 |
|
nucleic acid binding |
54 |
5E-2 |
||||||
|
|
||||||||
|
Cellular component |
||||||||
|
|
||||||||
|
285 |
342 |
195 |
||||||
|
chromosome |
11 |
2E-3 |
vacuole |
44 |
2E-8 |
chromosome |
8 |
4E-2 |
|
chromatin |
7 |
9E-3 |
lytic vacuole |
39 |
2E-7 |
|||
|
nucleus |
70 |
6E-3 |
lysosome |
39 |
1E-7 |
lytic vacuole |
17 |
4E-2 |
|
lytic vacuole |
20 |
2E-3 |
extracellular region |
32 |
2E-2 |
lysosome |
17 |
4E-2 |
|
lysosome |
20 |
2E-3 |
endosome |
8 |
4E-2 |
non-membrane bound organelle |
28 |
4E-2 |
|
|
||||||||
|
KEGG pathway |
||||||||
|
|
||||||||
|
122 |
185 |
125 |
||||||
|
N-glycan degradation |
5 |
2E-2 |
antigen processing |
9 |
2E-3 |
Toll-like receptor signaling |
10 |
2E-2 |
|
hematopoetic cell lineage |
8 |
3E-2 |
glycosphingolipid metabolism |
7 |
2E-2 |
glycosylaminoglycan degradation |
6 |
2E-2 |
|
hematopoetic cell lineage |
10 |
4E-2 |
||||||
|
|
||||||||
|
Biocarta pathway |
||||||||
|
|
||||||||
|
68 |
92 |
57 |
||||||
|
cyclins and cell cycle regulation |
9 |
2E-2 |
role of ERB2 in signal transduction |
9 |
5E-3 |
activation of Src |
4 |
3E-2 |
|
IL 3 signaling pathway |
7 |
1E-2 |
phospholipid signaling intermediates |
5 |
4E-2 |
|||
|
IL 6 signaling pathway |
8 |
1E-2 |
||||||
|
Erk and PI-3 kinase pathway |
7 |
2E-2 |
||||||
|
signaling pathway from G-protein families |
7 |
3E-2 |
||||||
|
|
||||||||
|
"n", number of genes involved in the corresponding annotation category; p, modified Fisher exact p-value of the gene enrichment for each category. |
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|
Čížková et al. BMC Genomics 2008 9:38 doi:10.1186/1471-2164-9-38 |
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