Research article
Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions
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* Corresponding author: Joan M Hevel joanie.hevel@usu.edu
1 Department of Chemistry and Biochemistry, Utah State University, Logan, USA
2 Center for Integrated BioSystems, Utah State University, Logan, USA
3 Department of Mathematics and Statistics, Utah State University, Logan, USA
BMC Genomics 2008, 9:376 doi:10.1186/1471-2164-9-376
Published: 7 August 2008Additional files
Additional File 1:
Low variability in the dataset. A comparison of the RMA expression values for the 54,675 probe sets on each of the six arrays. The tighter relationships within the Control and Treated groups are indicative of a data set with low variability. This low variability allowed the identification of a large number (2,546) of statistically significantly differentially expressed genes.
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Additional File 2:
List of genes for which expression was increased or decreased two-fold or greater.
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Additional File 3:
Global test to identify specific gene ontologies related to DNA repair and damage. A global test (Goeman et al., 2004; Goeman et al., 2005; Goeman and Oosting 2007) was used to identify specific gene ontologies related to DNA repair and damage. The p-values for each of the GO terms (abbreviated as the last four digits of each ontology's identifier) has been overlaid onto the hierarchical tree where the darkest blue node represents a p = 0.15 and the lightest represents a p = 0.016.
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