Table 4

Functional categories of genes regulated by the Zap1 transcriptional factor.

Functional Group

Zap1 Target Genes


First-line defenses: Zinc homeostasis

Zinc uptake

ZRT1, ZRT2, FET4, ZPS1

Mobilize zinc stores

ZRT3

Increase transcription response

ZAP1

Zinc sparing

ZRR1 (ADH1), ZRR2 (ADH3), ADH4

Zinc shock resistance

ZRC1

Other zinc homeostasis genes

IZH1, IZH2

Second-line defenses: Adaptive responses

Secretory pathway function

ZRG17, MNT2, MCD4, YJR061W

Cell wall function

PST1, BAG7, HSP12, SED1, SCW4, YOL155C, YIL169C, YJL171C

Stress resistance

GRE2, RAD27, TSA1, CTT1, UTH1, HSP26

Phospholipid metabolism

DPP1, EKI1, PIS1, YJL132W

Sulfur metabolism

LAP3, SAM3, YPR003C

Protein degradation

PRC1, PEP4, PRB1, ATG19, UBX6

Carbohydrate metabolism

NRG2, TKL2, ENO1, ENO2, TDH1

Purine/pyrimidine metabolism

URA10, ADE17, HNT1

Mitochondrial function

FMP43, PET20, PET10

Other

VEL1, MOH1, GPG1, COS6, ICY2, COS1, PHM7, PIG2, TIS11, ALD3, PUT4, COS2, ZIP1, COS4, COS8, TPO5, COS3, YNL254C, YOR387C, YLL020C, YOL131W, YBL029W, YHR214W-A, YMR181C, YLL053C , YBL048C, YMR086W, YNL234W


Genes shown in bold are new targets in this study

Wu et al. BMC Genomics 2008 9:370   doi:10.1186/1471-2164-9-370

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