The relationship between gene function and regulation by Zap1 in response to zinc status. The top line indicates the range of zinc levels in our experiments ranging from mild (LZM + 300 μM ZnCl2) to severe (LZM + 3 μM ZnCl2) zinc deficiency. The bars below indicate the range of zinc over which each functional response occurs. Sample data from Figure 4A are included to illustrate the patterns of differential regulation for genes from different functional categories. See Table 4 for details regarding the various adaptive responses and the particular genes associated with both homeostatic and adaptive responses.
Wu et al. BMC Genomics 2008 9:370 doi:10.1186/1471-2164-9-370