Correlation with clinical AML data. A. Published microarray data on 285 AML patients  were ordered using Gene Recommender according to the expression pattern of the 11 probe sets for RUNX1. The patients with t(8;21) are marked in orange and those with inv(16) in red. Probes co-regulated with RUNX1 are highly ranked (yellow bar), whereas probes showing an expression pattern the least similar to RUNX1 are ranked lowest (blue bar). B-C. Random permutations were performed to compare the rank of the genes differentially expressed in FPD platform and random set of genes. The histograms show the percentage of up- or down-regulated genes in FPD relative to their rank with "0" being the probes co-regulated with RUNX1 (yellow) and "1" being the probes the least similar to RUNX1 (blue). The trends observed in the histograms are represented as triangles or rectangle. D-E. Similar histograms showing percentage of up- or down-regulated genes in CBF relative to their rank.
Michaud et al. BMC Genomics 2008 9:363 doi:10.1186/1471-2164-9-363