Open Access Highly Accessed Research article

Integrative analysis of RUNX1 downstream pathways and target genes

Joëlle Michaud129, Ken M Simpson3, Robert Escher110, Karine Buchet-Poyau11124, Tim Beissbarth133, Catherine Carmichael12, Matthew E Ritchie3, Frédéric Schütz23, Ping Cannon1, Marjorie Liu5, Xiaofeng Shen6, Yoshiaki Ito7, Wendy H Raskind8, Marshall S Horwitz8, Motomi Osato7, David R Turner6, Terence P Speed3, Maria Kavallaris5, Gordon K Smyth3 and Hamish S Scott11415*

Author Affiliations

1 Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia

2 Department of Medical Biology, The University of Melbourne, 3050 Parkville, Victoria, Australia

3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia

4 Division of Medical Genetics, University of Geneva Medical School, 1211 Geneva, Switzerland

5 Experimental Therapeutics Program, Children's Cancer Institute Australia for Medical Research, 2031 NSW, Australia

6 Department of Hematology and Genetic Pathology, School of Medicine, Flinders University, 5001 South Australia, Australia

7 Molecular and Cell Biology, National University of Singapore, 117543 Singapore

8 Division of Medical Genetics, University of Washington, Seattle, USA

9 Center for Integrative Genomics, University of Lausanne, Switzerland

10 Internal Medicine, University Hospital, Berne, Switzerland

11 Université de Lyon, Lyon, F-69008, France; Université Lyon 1, Domaine Rockfeller, Lyon, F-69008, France

12 CNRS UMR 5201, Laboratoire de Génétique Moléculaire, Signalisation et Cancer, Lyon, F-69008, France

13 Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

14 Division of Molecular Pathology, the Institute of Medical and Veterinary Science and The Hanson Institute, Box 14 Rundle Mall Post Office, Adelaide, SA 5000, Australia

15 The School of Medicine the University of Adelaide, SA, 5005, Australia

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BMC Genomics 2008, 9:363  doi:10.1186/1471-2164-9-363

Published: 31 July 2008

Additional files

Additional File 1:

Additional Methods, Figures S1 to S4 and Tables S3 to S6. Additional figures and tables to support the statistical and bioinformatics analyses described in the manuscript.

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Additional File 2:

Table S1. Gene expression profiling results. Summary of the gene expression profiling results, oPOSSUM and corresponding mouse Affymetrix data for each clone Accession number present on the human cDNA array.

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Additional File 3:

Table S2. Gene expression profiling data for E8.5 and E12 Runx1 knockout embryos.

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Additional File 4:

Figure S4. Supporting graphs for the Gene Set Enrichment analysis.

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Additional File 5:

Figure S5. Expression pattern of RUNX1 and a subset of differentially expressed genes.

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