Table 3

Selected Parkinson's disease two-locus combinations.

SNP1

SNP2

Effect

Genetic Model

Odds Ratio

2-locus X2

Case-only X2


rs6542522

rs3923511

E

TC*GA

0.28

24.97

13.07

rs10799573

rs1341622

E

CC*CT

5.22

23.08

10.61

rs12520264

rs2992630

E

AG*GA

0.22

23.86

23.12

rs324454

rs12672177

E

GG*AG

0.21

24.31

11.55

rs6656554

rs3898966

E

GT*TC

3.83

23.44

22.34

rs7650598

rs12353255

E

AG*AG

3.99

23.94

9.40

rs2439525

rs1327918

E

TT*CC

2.39

22.04

7.13

rs10201616

rs4495512

E

CT*TT

5.04

24.08

8.63

rs11167062

rs1270919

E

TC*GT

0.20

21.83

20.65

rs2419117

rs10512174

E

GT*CC

5.55

23.33

9.33

rs1370699

rs1673130

C

CC*CC

0.35

25.50

30.15

rs1590957

rs8043401

C

TT*AG

0.32

24.17

28.18

rs1557615

rs2582597

C

TC*AG

0.35

21.76

26.38

rs11781101

rs4775501

C

CC*CC

0.22

23.99

25.69

rs1370699

rs7897163

C

CC*CC

0.34

30.65

25.68

rs13197142

rs2206699

C

GG*AA

2.33

21.85

25.16

rs732594

rs12373417

C

AA*GG

3.62

22.31

25.16

rs10498269

rs1551355

C

TC*CC

0.38

23.42

25.00

rs2555614

rs331617

C

AA*TT

0.35

24.15

24.22

rs3894377

rs10774863

C

AG*CT

0.31

25.47

23.84

rs4799327

rs2301661

S

AG*CC

4.32

20.65

33.62

rs2336865

rs7973385

S

GA*TC

3.22

30.71

27.77

rs6779648

rs270406

S

GG*AG

0.26

26.57

22.49

rs12599027

rs767055

S

TT*TT

0.23

26.23

24.34

rs3891371

rs4724620

S

AG*CC

0.29

35.76

23.92

rs2297518

rs660454

S

AG*TT

0.12

23.92

23.72

rs357968

rs1159145

S

AA*AA

0.26

30.29

23.47

rs1476097

rs5766305

S

TT*TT

0.37

23.93

23.19

rs2955005

rs2169793

S

GT*AG

3.29

25.74

22.76

rs2560790

rs9390939

S

AA*CA

0.32

23.35

22.62


A selection of two-locus marker combinations consistently and significantly associated to Parkinson's disease (p < 10-6) and displaying an epistatic (E) effect, or conditional (C) or simultaneous (S) effects with significant deviations of a multiplicative model. The genetic model tested is specified as SNP1 genotype * SNP2 genotype.

Gay├ín et al. BMC Genomics 2008 9:360   doi:10.1186/1471-2164-9-360

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