Table 1

Power Analysis.

Power (%)

Noise

Model 1

Model 2

Model 3


None

100

100

99

GE

100

100

96

MS

100

100

97

PC

89

100

49

GH

100

100

82

GE+GH+PC+MS

51

71

34


Power of HFCC to detect a two-locus interaction at an alpha level of 0.01 under 3 genetic epistasis models and different sources of noise: no noise (None), genotyping error (GE), missing data (MS), phenocopy (PC), genetic heterogeneity (GH), and all sources of noise simultenously (GE+GH+PC+MS). For the datasets with genetic heterogeneity, we reported the power to detect either of the two simulated two-locus effects. Model 1 is a heterozygote-homozygote risk (i.e., risk genotypes ABCC, ABDD, AACD and BBCD); Model 2 represents a "2 and only 2"-allele risk (i.e., A and C) from any of two loci (i.e., risk genotypes AADD, ABCD, and BBCC); Model 3 represents a protective double-heterozygote (i.e., protective genotype ABCD).

Gay├ín et al. BMC Genomics 2008 9:360   doi:10.1186/1471-2164-9-360

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