Research article
Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis
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* Corresponding authors: Ez-Zoubir Amri Ez-Zoubir.Amri@unice.fr - Zlatko Trajanoski zlatko.trajanoski@tugraz.at
- † Equal contributors
1 Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
2 ISBDC, Université de Nice Sophia-Antipolis, CNRS, 28 avenue de Valrose, 06100 Nice, France
3 Genomics Unit, Centro Nacional de Investiganciones Cardiovasculares, Madrid, Spain
4 Department of Orthopaedics, Medical University of Graz, Graz, Austria
BMC Genomics 2008, 9:340 doi:10.1186/1471-2164-9-340
Published: 17 July 2008Additional files
Additional file 1:
Real-time RT-PCR of 19 adipogenic and 14 osteogenic marker genes during adipocyte and osteoblast differentiation. A) Expression profiles of 21 adipogenic marker genes during adipocyte differentiation are displayed for the time points 5 (day+2), 7 (day+10), and 8 (day+15) after differentiation induction; B) Expression profiles of 14 osteogenic marker genes during osteoblast differentiation are displayed for the time points 5 (day+2), 7 (day+15), and 8 (day+24) after differentiation induction.
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Additional file 2:
Real-time RT-PCR and microarray data. Real-time RT-PCR and microarray data of 41 adipogenic, 22 osteogenic marker genes, and 37 potential self renewal-related genes with common profile during adipocyte and osteoblast differentiation.
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Additional file 3:
Heat map of expression data. Expression values for 1,606 genes in eight distinct clusters.
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Additional file 4:
miRNA motifs in up- and down-regulated gene clusters. Number of miRNA motifs in up- and down-regulated gene clusters in both lineages before and after commitment.
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Additional file 5:
Significantly over-represented miRNA motifs. Significantly over-represented miRNA motifs.
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Additional file 6:
Significantly over-represented transcription factor binding sites. Significantly over-represented transcription factor binding sites of 26 genes with a specific profile for the adipogenic commitment.
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Additional file 7:
Significantly over-represented transcription factor binding sites. Significantly over-represented transcription factor binding sites of 39 genes with a specific profile for the osteogenic commitment.
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