Analysis of simulated EST data. Results of analysis of randomized EST data. The number of true positives and the true positive rate (equal to one minus the false discovery rate) as a function of the likelihood ratio test statistic were estimated from 1000 randomizations of the matrices of counts of ESTs mapping to alternative SNP alleles and alternative splice isoforms. The solid line shows the number of true positives obtained when the true positive rate is 0.8 (i.e. at a false discovery rate of 0.2).
Nembaware et al. BMC Genomics 2008 9:265 doi:10.1186/1471-2164-9-265