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Cox regression analysis. Univariate and multivariate Cox regression analysis for time to distant metastases in 255 patients. |
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| Univariate analysis |
Multivariate analysis# |
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| Hazard ratio (95%CI) |
p |
Hazard ratio (95%CI) |
p |
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| Histological grade (1 vs. 2 vs. 3) |
3.14 (1.37–7.17) |
0.007 |
0.94 (0.36–2.42) |
0.9 |
| Tumor size (≤ 20 mm vs. ≥ 20 mm) |
2.18 (1.27–3.75) |
0.005 |
1.58(0.83–3) |
0.2 |
| Nodal status (positive vs. negative) |
1.62 (0.95–2.79) |
0.08 |
1.30 (0.71–2.37) |
0.4 |
| ER high vs. low expression |
0.86 (1.18–0.522) |
0.5 |
0.97 (0.56–1.7) |
0.9 |
| PgR high vs. low expression |
0.42 (0.25–0.7) |
0.0007 |
0.49 (0.26–0.9) |
0.02 |
| HER2 high vs. low expression |
0.88 (0.55–1.42) |
0.6 |
0.66 (0.37–1.18) |
0.2 |
| 13 cluster gene classifier* |
3.86 (2.32–6.41) |
<0.0001 |
3.26 (1.76–6.05) |
0.0002 |
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#Multivariate model contained included 210 patients due to missing values, stratified by population. *Binary classification using leave-one-out cross-validation. **Age was not included in the model as 92% of patients were ≥ 50 years of age. ER: estrogen receptor status represented by ESR1 Affymetrix probe set 205225_at. PgR: progesterone receptor status represented by PGR Affymetrix probe set 208305_at. HER2: represented by ERBB2 Affymetrix probe set 216836_s_at. For ER, PgR and HER2, high vs. low expression groups was defined by generating groups at the median value. | ||||
Loi et al. BMC Genomics 2008 9:239 doi:10.1186/1471-2164-9-239 |
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