Table 4

correlated pair by tissue-specific regulation

Tissue M

Tissue N

Pooled

exons

+D

-D

+D

-D

+D

-D

+U

9

81

9

1

18

82

-U

1

9

81

9

82

18

* +/- means the upstream (U) or downstream (D) exon in a pair is included/excluded in the transcript. In tissue M, the inclusion levels are 0.9 for U and 0.1 for D. In tissue N, the levels in 0.1 for U and 0.9 for D. The correlation coefficients between U and D are 0 in both M and N. But in pooled observation, the data show a strong negative correlation (-0.64). The cause of correlation in pooled data is not by the direct interaction between the two exons but the tissue-specific regulation.

Peng et al. BMC Genomics 2008 9:191   doi:10.1186/1471-2164-9-191