Table 1

Potential inconsistencies for gene regulatory interactions given a gene expression study.

TF expr. t
 Target gene expr. g
 Regulation type r
 Contradiction?
+
 +
 -
 yes
+
 -
 +
 yes
-
 +
 +
 yes
-
 -
 -
 yes
+
 +
 +
 no
+
 -
 -
 no
-
 +
 -
 no
-
 -
 +
 no

This table illustrates all gene expression/regulation combinations for a transcription factor T (with relative expression level t), a target gene G (with relative expression level g), and a regulatory interaction of type r. For the first four rows, COMA would suggest that the gene regulation type r contradicts the given gene expression levels for the transcription factor T and the target gene G.

Baumbach and Apeltsin BMC Genomics 2008 9:184   doi:10.1186/1471-2164-9-184