Evolution of the hepcidin gene in primates
1 Genetic Unit, IRCCS Burlo Garofolo and Department of Reproductive and Developmental Sciences, University of Trieste, Trieste, Italy
2 Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Trieste, Italy
3 Department of Genetics, Federal University of Pernambuco, Recife, Brazil
BMC Genomics 2008, 9:120 doi:10.1186/1471-2164-9-120Published: 5 March 2008
Hepcidin/LEAP-1 is an iron regulatory hormone originally identified as an antimicrobial peptide. As part of a systematic analysis of the evolution of host defense peptides in primates, we have sequenced the orthologous gene from 14 species of non-human primates.
The sequence of the mature peptide is highly conserved amongst all the analyzed species, being identical to the human one in great apes and gibbons, with a single residue conservative variation in Old-World monkeys and with few substitutions in New-World monkeys.
Our analysis indicates that hepcidin's role as a regulatory hormone, which involves interaction with a conserved receptor (ferroportin), may result in conservation over most of its sequence, with the exception of the stretch between residues 15 and 18, which in New-World monkeys (as well as in other mammals) shows a significant variation, possibly indicating that this structural region is involved in other functions.