Table 4

The most abundant protein folds in the E. coli cytosol.

Scop Fold

Number of distinct proteins with this fold a

Rank (by mean copy number)


Barrel-sandwich hybrid

10

1

Ribonuclease H-like motif

11

2

OB-fold

27

3

Thioredoxin fold

15

4

NAD(P)-binding Rossmann-fold domains

41

5

Transmembrane beta-barrels

12

6

Ferredoxin-like

22

7

TIM beta/alpha-barrel

47

8

Flavodoxin-like

28

9

DNA/RNA-binding 3-helical bundle

20

10

P-loop containing nucleoside triphosphate hydrolases

57

11

FAD/NAD(P)-binding domain

14

12

PLP-dependent transferases

14

13

Class II aaRS and biotin synthetases

13

14

Adenine nucleotide alpha hydrolase-like

17

15

Periplasmic binding protein-like II

22

16

ATP-grasp

10

17

S-adenosyl-L-methionine-dependent methyltransferases

12

18


a All folds with 10 or more proteins were considered to avoid single outliers influencing the general trend.

Ishihama et al. BMC Genomics 2008 9:102   doi:10.1186/1471-2164-9-102

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