Table 2

TGF-β regulated genes (17) in HPL1D involved in regulation of actin cytoskeleton

Acc No

DAVID Gene Name

1 hr

4 hr

12 hr


W20454

FIBRONECTIN 1

1.23 ± 0

1.36 ± 0.04

2.1 ± 0.19

H58824

DIAPHANOUS HOMOLOG 1 (DROSOPHILA)

0.84 ± 0.1

1.57 ± 0.19

1 ± 0.11

N46724

RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 7

1.4 ± 0.07

0.96 ± 0.21

1 ± 0.07

AA045207

ACTIN RELATED PROTEIN 2/3 COMPLEX, SUBUNIT 5, 16KDA

1.3 ± 0.09

1.3 ± 0.23

1.55 ± 0.12

BM924824

RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 (RHO FAMILY, SMALL GTP BINDING PROTEIN RAC1)

1.11 ± 0.08

1.14 ± 0.03

1.55 ± 0.07

BQ017489

ACTININ, ALPHA 1

1.42 ± 0.03

1.02 ± 0.11

1.53 ± 0.2

H73128

INTEGRIN, BETA 5

1.06 ± 0.03

1.21 ± 0.03

1.47 ± 0.11

W56632

CD14 ANTIGEN

1.46 ± 0

1.15 ± 0

1.45 ± 0.06

AA046597

INTEGRIN, BETA 4

1.63 ± 0.14

1.57 ± 0

1.43 ± 0.07

H23109

FIBROBLAST GROWTH FACTOR 1 (ACIDIC)

1.55 ± 0.1

0.94 ± 0.08

1.42 ± 0.2

AA010526

GLUCOCORTICOID RECEPTOR DNA BINDING FACTOR 1

1.37 ± 0.26

1.29 ± 0.07

1.36 ± 0.02

W67710

PLATELET-DERIVED GROWTH FACTOR BETA POLYPEPTIDE (SIMIAN SARCOMA VIRAL (V-SIS) ONCOGENE HOMOLOG)

1.53 ± 0.07

1.17 ± 0.02

1.2 ± 0.01

AA037763

WAS PROTEIN FAMILY, MEMBER 2

1.41 ± 0.08

1.08 ± 0.02

1.18 ± 0.05

W39107

RAS HOMOLOG GENE FAMILY, MEMBER A

1.37 ± 0.05

1.07 ± 0.04

1.14 ± 0.16

AL598940

MYOSIN, LIGHT POLYPEPTIDE 1, ALKALI; SKELETAL, FAST

1.36 ± 0.05

1.06 ± 0.12

1.07 ± 0.02

AA131272

INTEGRIN, ALPHA 8

1.19 ± 0

1.38 ± 0.06

0.96 ± 0.02

H83405

FYVE, RHOGEF AND PH DOMAIN CONTAINING 1 (FACIOGENITAL DYSPLASIA)

0.45 ± 0.01

0.52 ± 0.17

0.25 ± 0


The list in the table shows the regulated genes as revealed by the DAVID tool. The columns show Genbank accession no., gene name, and fold change with respect to untreated controls at 1 hr, 4 hr and 12 hr time points following TGF-β treatment respectively. The regulation shown against each gene is depicted as fold change ± S.E. with respect to untreated cells. Each experimental value of the duplicates of the respective genes is shown in tables S1 and S3 (see additional file 1 and 3). The number in the parenthesis of the title represents the number of genes in the table.

Ranganathan et al. BMC Genomics 2007 8:98   doi:10.1186/1471-2164-8-98

Open Data