Table 4 |
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|
Chromosome bands from the CCA results. Potential asbestos hotspots, some of which contain known asbestos-related genes. Expected false discovery rate of < 38%. |
|||
|
Region |
P-value/q-value |
No. of genes in the region with the most significant contribution to the common correlation* |
Examples of genes |
|
|
|||
|
2p22 |
0.00260/0.3367 |
10 |
MAP4K3†, CEBPZ§,QPCT§ |
|
9p13 |
0.00700/0.3367 |
71 |
FANCG†, IGFBPL1†, CCL19†MELK† |
|
14q21 |
0.00720/0.3367 |
22 |
FANCM†, CDKL1† |
|
5p13 |
0.00880/0.3367 |
5 |
|
|
9q21 |
0.00970/0.3367 |
29 |
PCSK5† |
|
5q13 |
0.01010/0.3367 |
9 |
F2RL1 |
|
8q22 |
0.01160/0.3367 |
59 |
CTHRC1†, TP53INP1†, KLF10† |
|
2q36 |
0.01260/0.3367 |
29 |
MRPL44† |
|
6q13 |
0.01300/0.3367 |
9 |
|
|
2q31 |
0.01370/0.3367 |
28 |
KIAA1715, AGPS, ITGA4†, ITGA6† |
|
3q29 |
0.01410/0.3367 |
54 |
DLG1 |
|
3p25 |
0.01480/0.3367 |
67 |
COLQ†, CAMK1†, RAF1†, TMEM43,LOC51244 |
|
15q12 |
0.0176/0.3471 |
2 |
|
|
4q11 |
0.0178/0.3471 |
6 |
|
|
8p21 |
0.0196/0.35672 |
70 |
BNIP3L, GSR§ |
|
12q12 |
0.0225/0.3705 |
7 |
|
|
14q22 |
0.0258/0.3705 |
29 |
TXNDC |
|
2q34 |
0.0266/0.3705 |
1 |
|
|
15q13 |
0.0272/0.3705 |
9 |
|
|
5q15 |
0.0279/0.3705 |
2 |
KIAA0372§ |
|
3q23 |
0.0285/0.3705 |
4 |
|
|
|
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|
* see Additional file 5: CCA for complete lists of the genes † Known or related to a known asbestos-associated gene. ITGA4 also differentially expressed in asbestos-exposed lung cancer patients as compared to non-exposed lung cancer patients [10]. § The gene also shows differential copy number in CGH array data of asbestos-exposed lung cancer patients, (data not shown, available at request) |
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|
Nymark et al. BMC Genomics 2007 8:62 doi:10.1186/1471-2164-8-62 |
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