Research article
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines
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* Corresponding author: Sakari Knuutila sakari.knuutila@helsinki.fi
- † Equal contributors
1 Health and Work Ability, Biological Mechanisms and Prevention of Work-related Diseases, Finnish Institute of Occupational Health, Helsinki, Finland
2 Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
3 Helsinki Institute for Information Technology, Laboratory of Computer and Information Science, Helsinki University of Technology, Espoo, Finland
4 Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
BMC Genomics 2007, 8:62 doi:10.1186/1471-2164-8-62
Published: 1 March 2007Additional files
Additional File 1:
GO analysis. The file contains enriched biological processes in each time point and each cell line.
Format: XLS Size: 91KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional File 2:
A549 clusters. The file contains profiles from all significant clusters in cell line A549. The X-axis shows the time points from 0h-7 days) and the Y-axis shows an expression ratio profile that is representative of all probe sets in the cluster. Due to the correlation based distance measure used in the clustering method (Ernst et al, 2005), the scale of the Y-axis is not significant.
Format: EPS Size: 611KB Download file
Additional File 3:
Beas-2B clusters. The file contains profiles from all significant clusters in cell line Beas-2B. The X-axis shows the time points from 0h-48h and the Y-axis shows an expression ratio profile that is representative of all probe sets in the cluster. Due to the correlation based distance measure used in the clustering method (Ernst et al, 2005), the scale of the Y-axis is not significant.
Format: EPS Size: 813KB Download file
Additional File 4:
Cluster analysis. The file contains lists of all genes included in all significant clusters of each cell line.
Format: XLS Size: 6.7MB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional File 5:
Canonical correlation analysis. The file contains list of genes contributing to the enrichment of the chromosomal regions that contribute to the common correlation between the cell lines A549 and Beas-2B.
Format: XLS Size: 117KB Download file
This file can be viewed with: Microsoft Excel Viewer