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Selection of genes with fold change between unfused and fused sutures and between each unfused suture site. |
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| Gene Name |
Affymetrix ID |
Description |
Fold U-F |
P-value U-F |
Unfused Lambdoid |
Unfused Coronal |
Unfused Sagittal |
|
|
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| Signalling |
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| ANGPTNL2 |
213004_at |
angiopoietin-like 2 |
6.67 |
0.024 |
1.00 |
-1.45 |
-2.87 |
| EGFR |
201983_s_at |
epidermal growth factor receptor |
2.71 |
0.038 |
1.00 |
1.02 |
1.20 |
| EPHA3 |
206071_s_at |
EPH receptor A3 |
2.92 |
0.480 |
1.00 |
-2.06 |
-5.33 |
| EPHA4 |
206114_at |
EPH receptor A4 |
2.75 |
0.173 |
1.00 |
-1.19 |
-1.60 |
| EPHB2 |
209589_s_at |
EPH receptor B2 |
2.39 |
0.093 |
1.00 |
1.22 |
-1.12 |
| FGFR2 |
208228_s_at |
fibroblast growth factor receptor 2 |
3.36 |
0.294 |
1.00 |
-1.42 |
-3.72 |
| FZD1 |
204451_at |
frizzled homolog 1 (Drosophila) |
2.13 |
0.326 |
1.00 |
-1.08 |
-2.41 |
| IL11RA |
204773_at |
interleukin 11 receptor, alpha |
5.90 |
0.003 |
1.00 |
1.49 |
1.32 |
| TGFB2 |
209909_s_at |
transforming growth factor, beta 2 |
3.76 |
0.096 |
1.00 |
-1.01 |
-2.08 |
| FGFR1 |
222164_at |
fibroblast growth factor receptor 1 |
1.23 |
0.480 |
1.00 |
-1.29 |
1.12 |
| FGFR3 |
204379_s_at |
fibroblast growth factor receptor 3 |
1.42 |
0.480 |
1.00 |
1.23 |
1.33 |
| WNT5A |
205990_s_at |
wingless-type MMTV integration site family, member 5A |
1.24 |
0.857 |
1.00 |
-1.03 |
-5.18 |
| IL17R |
205707_at |
interleukin 17 receptor |
-2.67 |
0.480 |
1.00 |
-1.25 |
3.35 |
| OLFM4 |
212768_s_at |
olfactomedin 4 |
-6.69 |
0.480 |
1.00 |
-2.15 |
6.77 |
| WIF1 |
204712_at |
WNT inhibitory factor 1 |
-3.19 |
0.480 |
1.00 |
-1.27 |
5.37 |
| Structural |
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| COL2A1 |
213492_at |
collagen, type II, alpha 1 (primary osteoarthritis) |
7.21 |
0.390 |
1.00 |
-20.66 |
-3.84 |
| COL3A1 |
215077_at |
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV) |
6.32 |
0.072 |
1.00 |
1.24 |
-3.84 |
| COL8A2 |
221900_at |
collagen, type VIII, alpha 2 |
11.49 |
0.092 |
1.00 |
-1.23 |
-12.73 |
| COL10A1 |
217428_s_at |
collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) |
14.65 |
0.407 |
1.00 |
-41.66 |
-17.28 |
| FBLN1 |
202995_s_at |
fibulin 1 |
12.88 |
0.025 |
1.00 |
-1.39 |
-1.92 |
| FMOD |
202709_at |
fibromodulin |
5.41 |
0.024 |
1.00 |
-1.09 |
-1.70 |
| NELL2 |
203413_at |
NEL-like 2 (chicken) |
6.40 |
0.270 |
1.00 |
-4.21 |
-3.01 |
| PRELP |
204223_at |
proline arginine-rich end leucine-rich repeat protein |
10.65 |
0.009 |
1.00 |
1.20 |
-1.31 |
| THBS2 |
203083_at |
thrombospondin 2 |
6.62 |
0.069 |
1.00 |
-1.26 |
-2.47 |
| COL1A2 |
202404_s_at |
collagen, type I, alpha 2 |
1.05 |
0.480 |
1.00 |
-1.01 |
-1.06 |
| CORO1A |
209083_at |
coronin, actin binding protein, 1A |
-5.08 |
0.480 |
1.00 |
-1.05 |
11.73 |
| Transcription |
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| BHLH3 |
221530_s_at |
basic helix-loop-helix domain containing, class B, 3 |
5.95 |
0.093 |
1.00 |
-2.23 |
-4.76 |
| CART1 |
206837_at |
cartilage paired-class homeoprotein 1 |
2.06 |
0.533 |
1.00 |
16.21 |
2.38 |
| HLF |
204753_s_at |
hepatic leukemia factor |
3.54 |
0.210 |
1.00 |
-2.55 |
-6.81 |
| JUN |
201465_s_at |
v-jun sarcoma virus 17 oncogene homolog (avian) |
4.41 |
0.161 |
1.00 |
3.14 |
2.50 |
| PITX2 |
207558_s_at |
paired-like homeodomain transcription factor 2 |
3.45 |
0.279 |
1.00 |
1.63 |
-2.08 |
| SIX2 |
206510_at |
sine oculis homeobox homolog 2 (Drosophila) |
2.72 |
0.136 |
1.00 |
-1.09 |
-1.70 |
| FOS |
209189_at |
v-fos FBJ murine osteosarcoma viral oncogene homolog |
1.40 |
0.745 |
1.00 |
14.96 |
4.13 |
| FOSB |
202768_at |
FBJ murine osteosarcoma viral oncogene homolog B |
1.83 |
0.695 |
1.00 |
54.37 |
20.22 |
| FOXD1 |
206307_s_at |
forkhead box D1 |
1.49 |
0.499 |
1.00 |
-4.71 |
-5.17 |
| JUNB |
201473_at |
jun B proto-oncogene |
1.28 |
0.703 |
1.00 |
3.61 |
2.95 |
| MEOX2 |
206201_s_at |
mesenchyme homeo box 2 (growth arrest-specific homeo box) |
1.66 |
0.495 |
1.00 |
-3.99 |
-7.74 |
| MSX2 |
210319_x_at |
msh homeo box homolog 2 (Drosophila) |
1.95 |
0.464 |
1.00 |
-1.14 |
-2.23 |
| TWIST1 |
213943_at |
twist homolog 1 (Saethre-Chotzen syndrome) |
1.50 |
0.476 |
1.00 |
-1.20 |
-1.27 |
| LHX6 |
219884_at |
LIM homeobox 6 |
-1.80 |
0.050 |
1.00 |
-1.07 |
-1.03 |
| SHOX2 |
210135_s_at |
short stature homeobox 2 |
-3.44 |
0.480 |
1.00 |
-1.00 |
4.50 |
| PAX5 |
221969_at |
paired box gene 5 (B-cell lineage specific activator) |
-4.20 |
0.480 |
1.00 |
-1.69 |
6.25 |
| Catalytic Activity |
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| ROR1 |
205805_s_at |
receptor tyrosine kinase-like orphan receptor 1 |
2.26 |
0.095 |
1.00 |
1.21 |
-1.14 |
| HDHD1A |
203974_at |
haloacid dehalogenase-like hydrolase domain containing 1A |
-1.78 |
0.018 |
1.00 |
1.05 |
1.05 |
| ALOX5 |
204446_s_at |
arachidonate 5-lipoxygenase |
-5.55 |
0.480 |
1.00 |
-1.30 |
6.76 |
| ANXA3 |
209369_at |
annexin A3 |
-7.17 |
0.480 |
1.00 |
-1.30 |
6.76 |
| Transporter |
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| C1QTNF3 |
220988_s_at |
C1q and tumor necrosis factor related protein 3 |
20.25 |
0.007 |
1.00 |
-1.52 |
-4.92 |
| RBP4 |
219140_s_at |
retinol binding protein 4 (plasma) KIAA1922 |
37.38 |
0.003 |
1.00 |
-1.35 |
-2.53 |
| APOC1 |
204416_x_at |
apolipoprotein C-I |
-2.01 |
0.480 |
1.00 |
1.08 |
5.06 |
| Binding |
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| AGC1 |
217161_x_at |
aggrecan 1 (chondroitin sulfate proteoglycan 1) |
6.16 |
0.024 |
1.00 |
-1.25 |
-1.56 |
| CCND1 |
208711_s_at |
cyclin D1 |
2.13 |
0.449 |
1.00 |
1.38 |
2.24 |
| GPC3 |
209220_at |
glypican 3 |
7.13 |
0.050 |
1.00 |
1.26 |
-3.34 |
| HAPLN1 |
205523_at |
hyaluronan and proteoglycan link protein 1 |
7.10 |
0.050 |
1.00 |
-1.96 |
-4.01 |
| INHBA |
210511_s_at |
inhibin, beta A (activin A, activin AB alpha polypeptide) |
6.94 |
0.006 |
1.00 |
-1.36 |
-3.03 |
| MFAP4 |
212713_at |
microfibrillar-associated protein 4 |
16.50 |
0.001 |
1.00 |
1.32 |
-1.86 |
| OGN |
218730_s_at |
osteoglycin (osteoinductive factor, mimecan) |
5.71 |
0.166 |
1.00 |
-1.41 |
-4.65 |
| POSTN |
214981_at |
periostin (osteoblast specific factor 2) |
5.87 |
0.101 |
1.00 |
-1.16 |
-1.60 |
| PTN |
209466_x_at |
pleiotrophin (osteoblast specific factor 1) |
6.25 |
0.031 |
1.00 |
-1.14 |
-1.78 |
| S100A10 |
200872_at |
S100 calcium binding protein A10 (annexin II ligand) |
2.01 |
0.096 |
1.00 |
-1.04 |
-1.60 |
| CCND3 |
201700_at |
cyclin D3 |
-2.60 |
0.480 |
1.00 |
-1.00 |
3.62 |
| FCN1 |
205237_at |
ficolin (collagen/fibrinogen domain containing) 1 |
-5.45 |
0.480 |
1.00 |
-1.46 |
12.39 |
| FGR |
208438_s_at |
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog |
-3.03 |
0.480 |
1.00 |
-1.13 |
5.75 |
| S100A12 |
205863_at |
S100 calcium binding protein A12 (calgranulin C) |
-8.86 |
0.480 |
1.00 |
-2.63 |
15.19 |
| Enzyme regulator |
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| MMP14 |
202827_s_at |
matrix metalloproteinase 14 (membrane-inserted) |
2.39 |
0.226 |
1.00 |
-1.22 |
-1.84 |
| TIMP3 |
201149_s_at |
tissue inhibitor of metalloproteinase 3 |
2.22 |
0.467 |
1.00 |
-1.71 |
-3.43 |
| CASP1 |
211366_x_at |
caspase 1, apoptosis-related cysteine protease |
-2.73 |
0.165 |
1.00 |
-1.30 |
1.01 |
| MME |
203434_s_at |
membrane metallo-endopeptidase (CD10) |
-3.23 |
0.476 |
1.00 |
-2.35 |
-1.29 |
| MMP8 |
207329_at |
matrix metalloproteinase 8 (neutrophil collagenase) |
-5.81 |
0.480 |
1.00 |
-2.36 |
1.69 |
| RASGRP2 |
208206_s_at |
RAS guanyl releasing protein 2 (calcium and DAG-regulated) |
-2.60 |
0.480 |
1.00 |
1.02 |
3.02 |
| Unknown Function |
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| CYFIP2 |
220999_s_at |
cytoplasmic FMR1 interacting protein 2 |
-2.68 |
0.031 |
1.00 |
1.14 |
1.09 |
|
Gene expression fold change (U-F) is presented for unfused sutures (n = 8) compared to fused/fusing sutures (n = 6), with corresponding P-values, and for combined unfused coronal (n = 4) and unfused sagittal (n = 2) sutures compared to unfused lambdoid sutures (n = 2). | |||||||
Coussens et al. BMC Genomics 2007 8:458 doi:10.1186/1471-2164-8-458 |
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