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Functional Classification of Genes Differentially Expressed in Stat3Δ/Δ mice |
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| GO Classification of Genes Up-regulated in Stat3Δ/Δ mice |
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| Term |
Count |
% |
PValue |
|
|
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| Biopolymer modification |
115 |
13.94 |
7.30E-13 |
| Cellular protein metabolism |
164 |
19.88 |
5.83E-10 |
| Protein transport |
52 |
6.30 |
2.49E-07 |
| Phosphate metabolism |
62 |
7.52 |
3.31E-07 |
| Chemotaxis |
17 |
2.06 |
1.38E-06 |
| Protein kinase cascade |
24 |
2.91 |
6.83E-06 |
| Apoptosis |
40 |
4.85 |
1.69E-05 |
| Regulation of apoptosis |
29 |
3.52 |
4.93E-05 |
| Positive regulation of cellular metabolism |
25 |
3.03 |
9.95E-05 |
| Cell migration |
19 |
2.30 |
2.26E-03 |
| Transcription |
106 |
12.85 |
2.64E-03 |
|
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| GO Classification of Genes Down-regulated in Stat3Δ/Δ mice |
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| Term |
Count |
% |
PValue |
|
|
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| Cellular lipid metabolism |
33 |
9.97 |
3.60E-13 |
| Lipid biosynthesis |
21 |
6.34 |
3.59E-11 |
| Sterol metabolism |
10 |
3.02 |
2.96E-07 |
| Fatty acid metabolism |
14 |
4.23 |
5.35E-07 |
| Steroid metabolism |
12 |
3.63 |
6.83E-06 |
| Carboxylic acid metabolism |
18 |
5.44 |
5.84E-04 |
| Coenzyme metabolism |
10 |
3.02 |
2.51E-03 |
| Cellular carbohydrate metabolism |
12 |
3.63 |
3.98E-03 |
| Electron transport |
14 |
4.23 |
2.64E-02 |
| Phosphate metabolism |
21 |
6.34 |
3.27E-02 |
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Note: Gene Ontology Analysis was preformed using public available web-based tool DAVID [81]. Overrepresented biological processes were selected at the threshold of Fisher Exact Test P-Value ≤ 0.05 and minimum gene counts belonging to an annotation term ≥ 2%. | |||
Xu et al. BMC Genomics 2007 8:455 doi:10.1186/1471-2164-8-455 |
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