Table 1

DNA-binding TF-encoding genes in human, mouse and fugu genomes. The TFs were classified based on their DNA-binding domains using a classification scheme adapted from Messina et al. [1]

TF family

Human

Mouse

Fugu


AP-2

5

5

6

ARID

11

9

15

Beta-scaffold – CCAAT

8

8

9

Beta-scaffold – MADS

5

5

9

Beta-scaffold – p53

3

3

3

Beta-scaffold – RUNT

3

3

5

Beta-scaffold – Others

28

28

31

BHLH

96

94

134

BZIP

69

65

83

Dwarfin

8

8

13

E2F

11

9

11

Forkhead

40

35

60

GCM

2

2

2

Heat shock factor

7

4

10

High mobility group box

35

39

56

Homeobox

221

199

282

Nuclear hormone receptor

49

49

69

Paired box

9

9

14

RFX

6

6

7

T-box

16

15

19

TEA

4

4

5

Trp cluster – Ets

29

29

31

Trp cluster – IRF

9

9

15

Trp cluster – Myb

11

11

13

ZnF-C2H2

472

290

254

ZnF-C3H

6

4

7

ZnF-DM

9

7

6

ZnF-GATA

10

10

12

ZnF-Others

61

55

73

Others (e.g., SAND, RBPSUH)

84

72

74


Total

1,327

1,086

1,328


Lee et al. BMC Genomics 2007 8:441   doi:10.1186/1471-2164-8-441

Open Data