Open Access Research article

Genome-wide changes in expression profile of murine endogenous retroviruses (MuERVs) in distant organs after burn injury

Young-Kwan Lee, Alex Chew, Lauren Fitzsimon, Rita Thomas, David Greenhalgh and Kiho Cho*

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California and Department of Surgery, University of California, Davis, Sacramento, CA 95817, USA

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BMC Genomics 2007, 8:440 doi:10.1186/1471-2164-8-440

Published: 28 November 2007

Additional files

Additional file 1:

Figure S1: Multiple alignment of MuERV U3 sequences related to burn and/or no burn. The 31 unique MuERV U3 sequences isolated from tissues (liver, lung, and kidney) of burn and/or no burn mice were subjected to multiple alignment analysis. Yellow regions have a 100 % homology, white regions are non-similar sequences, blue regions indicate conserved sequences, and dashes represent absence of sequences. The locations of the direct repeat, unique region and TATA box are identified in dotted boxes. An insertion of 190 bp is also indicated in the middle of the alignment. Table S1: Profile of transcription regulatory elements of 31 MuERV U3 sequences. A total of 73 transcription regulatory elements were analyzed. Numbers in the box indicate frequency of each transcription regulatory element. Gray box indicates no occurrence of specific transcription regulatory elements. Table S2: Neighboring host genes within 110 kb upstream and downstream of integration sites of individual putative MuERVs. A total of 145 neighboring host genes were identified within the search range.

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