Table 2

Putative SmINSIG interaction partners or possible downstream pathway genes in schistosomes, according to the INSIG functions and pathways described in the literature for other organisms

Protein/gene

Accession [species]

Function

Acetyl-CoA acetyltransferase

[GenBank: AAX26758.2]/[GenBank: AAX30459.1] [S. japonicum] C611014.1* [S. mansoni]

Mevalonate pathway

HMG-CoA reductase

[Swissprot: P16237] [S. mansoni]

Mevalonate pathway

Mevalonate kinase

C608152.1* [S. mansoni]

Mevalonate pathway

P-Mevalonate kinase

[GenBank: AAW26333.1] [S. japonicum] C608797.1* [S. mansoni]

Mevalonate pathway

Mevalonate diphosphate decarboxylase

C608650.1* [S. mansoni]

Mevalonate pathway

IPP isomerase

[GenBank: AAX26888.1] [S. japonicum]

Mevalonate pathway

gp78 Autocrine motility factor receptor (AMF receptor)

C609954.1*/C608624.1* [S. mansoni]

HMG-CoA reductase degradation

SCAP

C714360.1* [S. mansoni]

SREBP processing

Acetyl-CoA synthetase

C718554.1* [S. mansoni] [GenBank: AAX27415.2] [S. japonicum]

Fatty acid synthesis

Acetyl/Propionyl-CoA carboxylase

C611533.1* [S. mansoni] [GenBank: AAX27462.2] [S. japonicum]

Fatty acid synthesis

*These S. mansoni Assembled EST contigs are accessible at our Schistosoma mansoni EST Genome Project website [63] and contain publicly available GenBank EST sequences from [9].

Venancio et al. BMC Genomics 2007 8:407   doi:10.1186/1471-2164-8-407