Table 3

Summary of the mutations identified in essential genes as a result of this study.

Gene

Description

Genomic Position (bp)

Chromosome

Mutant

Allele

Mutation

Protein Change

RNAi Phenotype

Mutagen


C16A3.3

RRP5 Ribosomal RNA Processing Enzyme

6383494..6389343

III

let-716

s2457

G-A

3rd Intron Splice Site

emb

EMS

s2626

TGG-TGA

W1489 (opal)

fum-1

Fumarase

7465428..7467668

III

let-768

s2482

TCG-TTG

S149L

emb

EMS

s2592

CGT-CAT

R151H

s2628

GGA-AGA

G88R

C29E4.8

Adenylate Kinase

7951844..7949909

III

let-754

s2622

AAG-AAA

R150C

emb

EMS

aco-2

Aconitase

7973646..7977254

III

let-722

s2448

GAA-AAA

E285K

emb

EMS

s2450

GGG-GGA

G663D

s2588

CGC-CGT

A687V


emb = embryonic lethality

EMS = Ethylmethane Sulphonate

Jones et al. BMC Genomics 2007 8:402   doi:10.1186/1471-2164-8-402

Open Data