Table 3

Cytogenetic and molecular data for the 16 TEL/AML1 (ETV6/RUNX1)-positive patients

Patients

TEL/AML1 (ETV6/RUNX1) Fusion gene

RISK GROUP

KARYOTYPE

AML1(RUNX1) Copy-Number FISH

TEL(ETV6) Deletion FISH


3

TEL/AML1

SR

45, XY, der(3)t(3;8),-8, add(12)p?12?13

3

YES

5

TEL/AML1

SR

46, XY

2

YES

9

NONE

SR

53, XXY,+6,+10,+10,+14,+18,+?i(21q)[16]/46, XY[7]

4

NO

12

TEL/AML1

SR

46, XY

2

NO

13

TEL/AML1

SR

49, XX,+10,+15,+der(21)[1]/49, XX, idem, del(12)[6]/50XX, idem,+18[15]/50XX, idem, del(12),+18[2]/46XX[6]

3

YES

17

TEL/AML1

SR

47, XY, add(8p),-10, del(11q),+21,+mar[18]/46XY[4]

2

YES

18

TEL/AML1

HR

46, XY, add(19)(p or q)

2

YES

23

TEL/AML1

SR

50, XY,+8,?der(12),+21,+mar[4]/46XY)[26]

3

NO

32

TEL/AML1

HR

47, XY, t(3;14)(q?13;q?23),+21[18]/46, XY)[1]

4

NO

33

TEL/AML1

SR

46, XY

2

NO

35

TEL/AML1

SR

46, XY

2

NO

40

TEL/AML1

SR

45, X,-X, del(6)(q12qter)

2

YES

41

TEL/AML1

SR

failure

2

NO

43

TEL/AML1

SR

46, X,?del(Xq)[20]/46, XX[16]

2

YES

47

TEL/AML1

SR

46, XY

2

NO

48

TEL/AML1

SR

46, XY[25]

2

NO

53

TEL/AML1

SR

46, XY, t(1;8)?(q31;q24)t(X;17)?(q21;p13) [20]/46, XY[3]

2

NO


FISH experiments determined AML1 (RUNX1) gene copy number and revealed whether or not native TEL (ETV6) was deleted. Increased AML1 copy number was scored when present in more than 50% of the cell population.

Gandemer et al. BMC Genomics 2007 8:385   doi:10.1186/1471-2164-8-385

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