Table 3

Cellular pathways

Cellular pathway

Detected number of genes in SAM-list

Expected number of genes based on NCBI reference list

P-value

Angiogenesis

16

4.12

0.00001

Wnt signaling

20

6.71

0.00002

T cell activation

10

2.26

0.00012

Inflammation mediated by chemokine and cytokine signaling pathway

16

5.9

0.00038

Endothelin signaling pathway

8

1.84

0.00145

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

5

0.81

0.00145

Integrin signaling pathway

12

4.44

0.00202

Alpha adrenergic receptor signaling pathway

4

0.53

0.00209

EGF receptor signaling pathway

8

2.56

0.00470

Unclassified

370

388.65

0.00476

Axon guidance mediated by semaphorins

5

1.15

0.00636

PDGF signaling pathway

9

3.38

0.00781

Ras pathway

6

1.73

0.00852

AR-dependent cellular pathways identified by PANTHER (Thomas et al. 2003) [11] as significantly over-represented in the SAM-list compared to the NCBI human reference gene list (table limited to genes with p < 0.01)

Holterhus et al. BMC Genomics 2007 8:376   doi:10.1186/1471-2164-8-376