Table 4

Effect of inhibition of NADH dehydrogenase on the cytotoxicity of palmitate and TG accumulation

Concentration

LDH release (DAY 1)

LDH release (DAY 2)

TG (Day 1) ug/mg protein

TG (Day 2) ug/mg protein

None

4.5 +/- 0.3

35.7 +/- 3.4

69.4 +/- 16.1

173.8 +/- 16.7

250 nM

3.4 +/- 0.3 *

24.9 +/- 1.4 *

63.3 +/- 14.2

191.1 +/- 12.1

500 nM

2.7 +/- 0.2 *

14.8 +/- 3.2 *

74.3 +/- 12.0

197.8 +/- 11.3

1000 nM

3.4 +/- 0.2 *

20.0 +/- 4.6 *

104.6 +/- 7.8 *

204.9 +/- 8.5 *

*, significantly different than the no inhibitor condition, p < 0.01.

Srivastava et al. BMC Genomics 2007 8:364   doi:10.1186/1471-2164-8-364