Figure 1.

Alignment of B. mori nAChR subunit protein sequences. D. melanogaster α1 is included for comparison. N-terminal signal peptides are underlined. Position of loops (LpA-F) involved in ligand binding and transmembrane motifs (TM1–4) forming the ion channel are indicated. Sites of Cys residues involved in Cys-loop are marked with asterisks and the vicinal Cys residues characteristic of α-type are showed in white letters. GEK motif associated with cation selectivity is indicated by inverted triangles. Putative N-glycosylation sites are highlighted in shade. Potential PKA, PKC, and CK2 phosphorylation sites are boxed and potential tyrosine kinase phosphorylation sites are enclosed in ovals.