Alignment of B. mori nAChR subunit protein sequences. D. melanogaster α1 is included for comparison. N-terminal signal peptides are underlined. Position of loops (LpA-F) involved in ligand binding and transmembrane motifs (TM1–4) forming the ion channel are indicated. Sites of Cys residues involved in Cys-loop are marked with asterisks and the vicinal Cys residues characteristic of α-type are showed in white letters. GEK motif associated with cation selectivity is indicated by inverted triangles. Putative N-glycosylation sites are highlighted in shade. Potential PKA, PKC, and CK2 phosphorylation sites are boxed and potential tyrosine kinase phosphorylation sites are enclosed in ovals.
Shao et al. BMC Genomics 2007 8:324 doi:10.1186/1471-2164-8-324