Figure 3.

Association between histone H4 hyperacetylation and gene expression in human myoblasts and myotubes. For all pairs of SNP-array probes and gene transcription starts at a given distance range, the plot shows the ratio of hybridizing over non-hybridizing SNP-array probes, for genes detected as transcribed (filled circles), or not transcribed (empty circles). The centre of the graph indicates the start of transcription for a gene with negative distances representing the upstream region and positive distances representing the downstream region. The detection of histone H4 modification is markedly higher in the [-0.3 Mb, +0.3 Mb] distance range of the start of transcription of expressed genes indicating a positive association between histone H4 hyperacetylation and gene expression. Each data point is computed from all pairs of SNP-Array probe to DNA microarray probeset at the given distance range, always more than 100. The data is provided as Supplementary Table S3. HypAcH4: hyperacetylated histone H4; noHypAcH4: non-hyperacetylated histone H4; Mb: megabases.