Open Access Highly Accessed Research article

The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns

Jackie Dolan1, Karen Walshe1, Samantha Alsbury2, Karsten Hokamp1, Sean O'Keeffe1, Tatsuya Okafuji1, Suzanne FC Miller1, Guy Tear2 and Kevin J Mitchell1*

Author Affiliations

1 Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland

2 MRC Centre for Developmental Neurobiology, New Hunts House, Guys Campus, King's College London SE1 1UL, UK

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BMC Genomics 2007, 8:320  doi:10.1186/1471-2164-8-320

Published: 14 September 2007

Additional files

Additional file 1:

Curated sequences of eLRR proteins. List of curated sequences of eLRR proteins in FASTA format.

Format: DOC Size: 506KB Download file

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Additional file 2:

LRRscan_out.html. Graphical comparison of HMMpfam and LRRscan results. A compressed archive (lrr_plots.tar.gz) containing 372 images in Portable Network Graphics (PNG) format, an information file (00README.txt) and two HTML-formatted pages, one with output from LRRscan (LRRscan_out.html) and one that links all the images together (00plots.html). After downloading, the archive must be to uncompressed and unpacked. Most modern operating systems (e.g. Windows XP, Mac OS X) will do this automatically when double-clicking on the file. Alternatively, you can use the free tool 'Stuffit Expander' (http://www.stuffit.com webcite) or your favourite unpacker. On Linux or Unix systems apply the following command: tar zxf lrr_plots.tar.gz. Please note that some browsers might uncompress the file during download without changing the file ending. If you have trouble unpacking the file try renaming it to lrr_plots.tar and double-click on it again. Unpacking the archive creates a new folder (lrr_plots) in which you can find a file called '00plots.html'. Open this file in a web-browser, either by double-clicking onto it or by using the 'File->Open File' menu (or equivalent) of your browser. This will bring up a web-page with plots of LRR motifs for 372 proteins. If you click on an image you can see the text output from LRRscan in a new window.

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Additional file 3:

Table S1. Complete list of genes, clustered at e-40.

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Additional file 4:

Table S2. Complete list of genes, clustered at e-25.

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Additional file 5:

Table S3. Complete list of genes, clustered at e-10.

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Additional file 6:

Table S4. List of clusters used in Figure 5.

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Additional file 7:

Table S5. Summary of fly gene expression

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Additional file 8:

Additional methods. In situ hybridisation protocols

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