Table 2

Genes showing significant differences in expression between rapid-forming PCTs (ABPC and ABLMYCPC) and slow-forming PCTs (TEPC, IL6PC and KiPC)

Higher in slow-forming PCT (TEPC, IL6PC, KiPC


Gene function

Rapid PCT

Slow PCT

Fold difference (slow/rapid)

Description

Unigene ID

Gene symbol

p-value


Angiogenesis


308.4

495.6

1.6

Neogenin

Mm.42249

Neo1

1.05E-05


Apoptosis


2872.8

5249.1

1.8

RIKEN cDNA A630035D09 gene

Mm.238213

Bcl2l1

4.67E-05


Cell cycle


583.6

2799.1

4.8

Megakaryocyte-associated tyrosine kinase

Mm.2918

Matk

< 1E-07

270.1

912.6

3.4

Protein kinase C, zeta

Mm.28561

Prkcz

< 1E-07

208.1

364.3

1.8

Acid phosphatase, prostate

Mm.19941

Acpp

2.10E-06

280.7

473.5

1.7

Cyclin D1

Mm.273049

Ccnd1

7.12E-05

1484.3

2441.1

1.6

Casein kinase 1, epsilon

Mm.30199

Csnk1e

3.50E-06


Immune response


204.1

535.4

2.6

Prolactin receptor

Mm.10516

Prlr

5.4E-06

124

267.7

2.2

Transforming growth factor, beta receptor III

Mm.200775

Tgfbr3

1.2E-06

2872.8

5249.1

1.8

RIKEN cDNA A630035D09 gene

Mm.238213

Bcl2l1

4.67E-05

707.2

1243.1

1.8

AU RNA binding protein/enoyl-coenzyme A hydratase

Mm.252034

Auh

3.2E-06

1000.1

1751.7

1.8

Aldehyde dehydrogenase 2, mitochondrial

Mm.284446

Aldh2

3.56E-05

2990.5

5228.6

1.7

Glucosidase, beta, acid

Mm.5031

Gba

< 1E-07

942.5

1629.7

1.7

AU RNA binding protein/enoyl-coenzyme A hydratase

Mm.252034

Auh

< 1E-07

7349

12562.5

1.7

CCAAT/enhancer binding protein (C/EBP), beta

Mm.347406

Cebpb

1E-07

752.1

1285.1

1.7

Profilin 1

Mm.2647

Pfn1

3.5E-06

912.2

1538.3

1.7

Aldehyde dehydrogenase 2, mitochondrial

Mm.284446

Aldh2

6.2E-05

2311.2

3862.5

1.7

Epidermal growth factor receptor pathway substrate 15

Mm.318250

Eps15

1.24E-05

166.2

274.5

1.7

Microphthalmia-associated transcription factor

Mm.333284

Mitf

7.9E-06

722.3

1097.6

1.5

Amyloid beta (A4) precursor protein-binding, family B, member 1

Mm.38469

Apbb1

7E-06

749.6

1135

1.5

Glutathione synthetase

Mm.252316

Gss

7.61E-05


Transcription factor


294

803.5

2.7

AT motif binding factor 1

Mm.196564

Atbf1

< 1e-07

247.9

639.4

2.6

E74-like factor 3

Mm.3963

Elf3

6.80E-06

844.6

1883

2.2

Pre B-cell leukemia transcription factor 1

Mm.43358

Pbx1

< 1E-07

765.9

1554.6

2.0

POU domain, class 2, transcription factor 2

Mm.208700

Pou2f2

2.30E-06

7349

12562.5

1.7

CCAAT/enhancer binding protein (C/EBP), beta

Mm.347406

Cebpb

1.00E-07

162.2

252.2

1.6

RIKEN cDNA 2310011G17 gene

Mm.254233

2310011G17 Rik

6.55E-05


Signal transduction


583.6

2799.1

4.8

Megakaryocyte-associated tyrosine kinase

Mm.2918

Matk

< 1E-07

270.1

912.6

3.4

Protein kinase C, zeta

Mm.28561

Prkcz

< 1E-07

1484.3

2441.1

1.6

Casein kinase 1, epsilon

Mm.30199

Csnk1e

3.50E-06

456.5

729.4

1.6

Homeodomain interacting protein kinase 3

Mm.257925

Hipk3

2.11E-05


Development


844.6

1883

2.2

Pre B-cell leukemia transcription factor 1

Mm.43358

Pbx1

< 1E-07


Higher in rapid-forming PCT (ABPC and ABLMYCPC)


Gene function

Rapid PCT

Slow PCT

Fold difference (rapid/slow)

Description

Unigene ID

Gene symbol

p-value


Angiogenesis


1868.3

902.8

2.1

Plasminogen activator, urokinase

Mm.4183

Plau

8.29E-05

9821.9

4360.2

2.3

CD53 antigen

Mm.316861

Cd53

3.40E-06


Apoptosis


2588.3

1681.2

1.5

BCL2-antagonist/killer 1

Mm.2443

Bak1

9.11E-05


Cell cycle


2231.6

1126.6

2.0

Proliferation-associated 2G4

Mm.4742

Pa2g4

2.76E-05

4858.7

2552.3

1.9

Adenylate kinase 2

Mm.29460

Ak2

< 1E-07

10477

6082.1

1.7

CDC28 protein kinase regulatory subunit 2

Mm.222228

Cks2

< 1E-07

1371.5

869.3

1.6

Casein kinase II, alpha 2, polypeptide

Mm.51136

Csnk2a2

1.90E-06


Immune response


3568.1

386

9.2

CD6 antigen

Mm.290897

Cd6

2.00E-07

984.7

186.1

5.3

Tubulin, alpha 3

Mm.287784

Tuba3

< 1E-07

2661.9

718.2

3.7

BH3 interacting domain death agonist

Mm.235081

Bid

< 1E-07

7492.6

2554.5

2.9

Acetyl-Coenzyme A dehydrogenase, medium chain

Mm.10530

Acadm

< 1E-07

3195.6

1346.2

2.4

Inositol (myo)-1(or 4)-monophosphatase 1

Mm.183042

Impa1

< 1E-07

2455

1064.3

2.3

RAS-related protein-1a

Mm.333868

Rap1a

< 1E-07

9821.9

4360.2

2.3

CD53 antigen

Mm.316861

Cd53

3.40E-06

7479.7

3365.9

2.2

Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Mm.207996

Tap1

< 1E-07

7347.8

3535.9

2.1

Superoxide dismutase 1, soluble

Mm.276325

Sod1

< 1E-07

365.9

179.9

2.0

Growth factor independent 1

Mm.2078

Gfi1

1.30E-05

2231.6

1126.6

2.0

Proliferation-associated 2G4

Mm.4742

Pa2g4

2.76E-05

1939.9

985.5

2.0

RAS-related protein-1a

Mm.333868

Rap1a

4.00E-07

450.3

261.9

1.7

Ets variant gene 4 (E1A enhancer binding protein, E1AF)

Mm.5025

Etv4

1.40E-06

3031.7

1830.6

1.7

Wiskott-Aldrich syndrome homolog (human)

Mm.4735

Was

5.13E-06

3136.7

1944.6

1.6

Chromosome segregation 1-like (S. cerevisiae)

Mm.22417

Cse1l

2.67E-05

5738.7

3586.7

1.6

Survival motor neuron 1

Mm.2025

Smn1

2.75E-05

395.2

252.8

1.6

Dihydrofolate reductase

Mm.23695

Dhfr

2.70E-06

2017.5

1297.8

1.6

FK506 binding protein 12-rapamycin associated protein 1

Mm.21158

Frap1

8.46E-05

2588.3

1681.2

1.5

BCL2-antagonist/killer 1

Mm.2443

Bak1

9.11E-05

4410.1

2873.4

1.5

Ribonucleotide reductase M1

Mm.197486

Rrm1

5.14E-05

5971.6

3940.2

1.5

Integrin beta 4 binding protein

Mm.271674

Itgb4bp

6.94E-05

18860.1

12494.5

1.5

Triosephosphate isomerase 1

Mm.4222

Tpi1

8.30E-06


Transcription factor


6231.6

1885.8

3.3

Lymphoblastomic leukemia

Mm.4925

Lyl1

< 1E-07

3274.2

1544.3

2.1

Chromodomain helicase DNA binding protein 1

Mm.8137

Chd1

< 1E-07

450.3

261.9

1.7

Ets variant gene 4 (E1A enhancer binding protein, E1AF)

Mm.5025

Etv4

1.40E-06

3136.7

1944.6

1.6

Chromosome segregation 1-like (S. cerevisiae)

Mm.22417

Cse1l

2.67E-05


Signal transduction


4858.7

2552.3

1.9

Adenylate kinase 2

Mm.29460

Ak2

< 1E-07

10477

6082.1

1.7

CDC28 protein kinase regulatory subunit 2

Mm.222228

Cks2

< 1E-07

3031.7

1830.6

1.7

Wiskott-Aldrich syndrome homolog (human)

Mm.4735

Was

5.13E-05

1371.5

869.3

1.6

Casein kinase II, alpha 2, polypeptide

Mm.51136

Csnk2a2

1.90E-06


DNA replication


3805.2

2420.4

1.6

Small nuclear ribonucleoprotein polypeptide A'

Mm.821

Snrpa1

< 1e-07

8247.5

4325.9

1.9

Replication protein A1

Mm.180734

Rpa1

4.20E-06


Class comparison between slow-forming PCTs (TEPC, IL6PC and KiPC) and rapid-forming PCTs (ABPC and ABLMYCPC) by two-sample t-test generated 1195 genes showing significant differences (p- value < 0.001). Among these 1195 genes, the genes showing more than 1.5 fold increase and p-value < 0.0001 were selected in this table. The genes in each category of gene function were assigned based on the annotation of CGAP.

Park et al. BMC Genomics 2007 8:302   doi:10.1186/1471-2164-8-302

Open Data