Comparison of gene coverage between KRM1 and KRM2 for GABA receptor signaling (brain-centric) and antigen presentation (spleen-centric) pathways highlights greater coverage and specificity of probes on the KRM2 array designed from genomic data. These networks are laid out with the KRM1 results on top and the KRM2 below. Genes indicated in yellow were more prominently expressed in spleen while the blue denotes higher expression levels in brain. The antigen presentation network (in yellow) shows a 66% greater coverage on the KRM2 array, while the GABA receptor signaling network (in blue) is completely void on KRM1 and fully covered on KRM2.
Wallace et al. BMC Genomics 2007 8:28 doi:10.1186/1471-2164-8-28