The interplay of cell types and pathways in SALS pathology. Combining pathways and candidate genes differentially expressed in the motor cortex of SALS patients reveals a complex interplay of cellular processes and cell types. Candidate genes corresponding to major pathways discussed in the main text are color-coded, placed in the cell type(s) where they most likely exert their influence, and their individual up- () or down-regulation () is indicated. Genes EIF4A2, GNAS, and NAP1L5 are left out for clarity.
Lederer et al. BMC Genomics 2007 8:26 doi:10.1186/1471-2164-8-26