Table 3

GSEA of DEX-treated primary chondrocytes.

Gene set name

Size

ES

NES

NOM p-val

FDR q-val


Metabolism

196

0.471

1.935

<0.001

0.016

Extracellualr Matrix

228

0.451

1.878

<0.001

0.016

Fkbp

33

0.559

1.696

0.011

0.054

Integrin_Related

173

0.407

1.643

<0.001

0.001

Angiogenesis

57

0.479

1.610

0.012

0.065

Kinase_1

499

0.343

1.549

<0.001

0.092

Tumor Suppressor

48

0.457

1.492

0.037

0.126

Catalytic

245

0.337

1.420

0.008

0.172

Hepatocyte

19

0.529

1.406

0.104

0.161

D3 Vs D15_2

497

0.304

1.368

0.004

0.194

Igf

48

0.412

1.348

0.093

0.208

Cyclin

224

0.322

1.344

0.028

0.199

Actin_Cytoskel

38

0.426

1.325

0.124

0.213

Structure

151

0.332

1.312

0.053

0.219

Cytoplasm

411

0.292

1.300

0.023

0.224

Adipose

70

0.368

1.285

0.116

0.232

Gtpase Activity

73

0.363

1.280

0.113

0.230

Cartilage

28

0.432

1.262

0.169

0.246

Chemokine

31

-0.779

-2.40

<0.001

0

Cytokine

127

-0.579

-2.31

<0.001

0

Growth Factor

106

-0.517

-2.01

<0.001

7.698E-04

Interleukinrelated

175

-0.469

-1.98

<0.001

9.475E-04

Bone

16

-0.577

-1.51

0.051

8.945E-02

Creb_Atf3

30

-0.469

-1.43

0.065

1.300E-01

Dusp

20

-0.508

-1.40

0.102

1.418E-01

Blood

111

-0.351

-1.37

0.037

1.425E-01

3vs15_1.5x_3

496

-0.288

-1.35

0.002

1.518E-01

Protease_2

268

-0.306

-1.35

0.015

1.411E-01

Nuc_Hormone_Receptor

55

-0.381

-1.32

0.086

1.570E-01

Tf_Repress

55

-0.380

-1.32

0.091

1.498E-01

3vs15_1.5x_4

497

-0.272

-1.28

0.011

1.817E-01

Erk_Related

40

-0.385

-1.25

0.157

2.169E-01


ES, enrichment score

NES, normalized enrichment score

FDR q-val, false discovery rate and multiple testing corrections (q-value)

NOM p-val; the uncorrected p-value

James et al. BMC Genomics 2007 8:205   doi:10.1186/1471-2164-8-205

Open Data