Table 4

Phenotypic changes in mice carrying loss-of-function mutations of the predicted brain and PBMC target genes.

Phenotype

Brain

PBMC

Random


Nervous system1

21

5

5

Immune system2

2

8

7

Nervous/immune3

2

6

2

Embryonic lethal4

2

0

4

Other systems5

3

4

11

Normal6

1

7

4


Total gene number

31

30

33


1 Phenotype in nervous system, including behavioral and neurological defects, but no defects in immune and hematopoietic system.

2 Phenotype in immune system, including the hematopoietic system, but no nervous system or behavioral/neurological defects.

3 Phenotype from both 1 and 2 can be seen.

4 Embryonic lethal with no other phenotypic records, indicating that the embryo dies too early to observe meaningful phenotype.

5 Defects in other tissues/organs/systems than nervous and immune systems.

6 The phenotypic record showed no defect was seen.

Liang et al. BMC Genomics 2007 8:166   doi:10.1186/1471-2164-8-166

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