Database

bZIPDB : A database of regulatory information for human bZIP transcription factors

Taewoo Ryu¹ , Juhyun Jung¹ , Sunjae Lee¹ , Ho Jung Nam¹ , Sun Woo Hong² , Jae Wook Yoo² , Dong-ki Lee² and Doheon Lee¹

¹Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon, 305-701, Korea

²Department of Chemistry, Pohang University of Science and Technology, Hyo-ja-dong, Nam-gu, Pohang, 790-784, Korea

author email corresponding author email

BMC Genomics 2007, 8:136doi:10.1186/1471-2164-8-136

Published:	30 May 2007

Abstract

Background

Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detailed characterization of these TFs, further public resources are required.

Description

We constructed a database, designated bZIPDB, containing information on 49 human bZIP TFs, by means of automated literature collection and manual curation. bZIPDB aims to provide public data required for deciphering the gene regulatory network of the human bZIP family, e.g., evaluation or reference information for the identification of regulatory modules. The resources provided by bZIPDB include (1) protein interaction data including direct binding, phosphorylation and functional associations between bZIP TFs and other cellular proteins, along with other types of interactions, (2) bZIP TF-target gene relationships, (3) the cellular network of bZIP TFs in particular cell lines, and (4) gene information and ontology. In the current version of the database, 721 protein interactions and 560 TF-target gene relationships are recorded. bZIPDB is annually updated for the newly discovered information.

Conclusion

bZIPDB is a repository of detailed regulatory information for human bZIP TFs that is collected and processed from the literature, designed to facilitate analysis of this protein family. bZIPDB is available for public use at http://biosoft.kaist.ac.kr/bzipdb webcite.