Table 2

Functional classification of CAGpolyQ genes: Gene Ontology over-representation analysis.

Gene Ontology term (levels) GO ID

Candidate genes in GO term

Fold* Enrichment

Biological Process

regulation of biological process (1) GO:0050789

37

2.3

regulation of physiological process (2) GO:0050791

36

2.5

regulation of metabolism (3) GO:0019222

29

3.0

positive regulation of metabolism (4) GO:0009893

7

6.5

nucleobase, nucleoside, nucleotide and nucleic acid

metabolism (4) GO:0006139

34

2.5

Molecular Function

transcription regulator activity (1) GO:0030528

24

4.0

transcription cofactor activity (2,4) GO:0003712

11

8.8

transcription coactivator activity (3,5) GO:0003713

9

13.4

nucleic acid binding (2) GO:0003676

35

2.8

DNA binding (3) GO:0003677

28

3.1

transcription factor binding (3) GO:0008134

12

8.3

Cellular Component

organelle (1) GO:0043226

43

1.7

membrane-bound organelle (2) GO:0043227

43

1.9

intracellular (2) GO:0005622

47

1.5

intracellular organelle (2,3) GO:0043229

43

1.7

intracellular membrane-bound organelle (3,4) GO:0043231

43

1.9

nucleus (3,4,5) GO:0005634

41

2.7

nucleoplasm (4,5,6) GO:0005654

11

4.1

All levels for each GO term are indicated, with boldface indicating one path through the GO

*p < 0.00004 for all GO terms listed except nucleoplasm, p = 0.0001.

Butland et al. BMC Genomics 2007 8:126   doi:10.1186/1471-2164-8-126