Open Access Highly Accessed Research article

The molecular portraits of breast tumors are conserved across microarray platforms

Zhiyuan Hu12, Cheng Fan1, Daniel S Oh12, JS Marron3, Xiaping He12, Bahjat F Qaqish4, Chad Livasy5, Lisa A Carey6, Evangeline Reynolds6, Lynn Dressler6, Andrew Nobel3, Joel Parker7, Matthew G Ewend6, Lynda R Sawyer6, Junyuan Wu1, Yudong Liu1, Rita Nanda8, Maria Tretiakova8, Alejandra Ruiz Orrico9, Donna Dreher9, Juan P Palazzo9, Laurent Perreard10, Edward Nelson11, Mary Mone11, Heidi Hansen11, Michael Mullins12, John F Quackenbush12, Matthew J Ellis13, Olufunmilayo I Olopade8, Philip S Bernard12 and Charles M Perou125*

Author Affiliations

1 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA

2 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA

3 Department of Statistics and Operations Research, University of North Carolina, Chapel Hill, NC 27599, USA

4 Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA

5 Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

6 Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

7 Constella Health Sciences, 2605 Meridian Parkway, Durham, NC 27713, USA

8 Section of Hematology/Oncology, Department of Medicine, Committees on Genetics and Cancer Biology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637-1463, USA

9 Department of Pathology, Thomas Jefferson University, 132 South 10th Street Philadelphia, PA 19107, USA

10 The ARUP Institute for Clinical and Experimental Pathology, 500 Chipeta Way, Salt Lake City, Utah 84108, USA

11 Department of Surgery, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, Utah 84132, USA

12 Department of Pathology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, Utah 84132, USA

13 Department of Medicine, Division of Oncology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri, USA

For all author emails, please log on.

BMC Genomics 2006, 7:96  doi:10.1186/1471-2164-7-96

Published: 27 April 2006

Additional files

Additional File 2:

Supplemental Table 1. Clinical and microarray information associated with each patient in the 105-sample training dataset.

Format: PDF Size: 131KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional File 1:

Supplemental Figure 1. Complete hierarchical cluster diagram of the 315-sample combined test set analyzed using the Intrinsic/UNC gene set, which was reduced to 306 genes based upon the gene overlap between datasets. Sorlie et al. sample names begin with the letters "BC", Sotiriou et al. sample names begin with "Exp", and van't Veer et al. sample names begin with "sample".

Format: PDF Size: 226KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data