ROC curve for accuracy in detection of differential expression at different FDR thresholds. Significantly differentially expressed genes are defined as p < 0.05 in student t-test using TaqMan Gene Expression data set as a reference. For each microarray platform, on top of the p-value criteria (p < 0.05 in student t-test), a series of FDR (0–20%) were also applied to achieve increasing stringency. Each point on the ROC curve of a given microarray platform represents the sensitivity (true positive rate) and 1- specificity (false positive rate) at a given FDR level (labeled on dashed lines).
Wang et al. BMC Genomics 2006 7:59 doi:10.1186/1471-2164-7-59