Sensitivity in detection of differential expression for different fold changes. For each platform, significantly differentially expressed genes for any given pair-wise tissues are determined using t-test at 95% significance level (p-value = 0.05). Using one-sample z-test, genes showing "at least F fold change" with 95% confidence are grouped based on TaqMan® Gene Expression Assays data set. True Positive Rates of each microarray platform was plotted as a function of Fold Change cut-off (range from 1.2 – 10) for each pair-wise tissues.
Wang et al. BMC Genomics 2006 7:59 doi:10.1186/1471-2164-7-59