Figure 4.

Comparison of DPY19L family members. A) RT-PCR analysis of the four human genes. B) Phylogenetic analysis of DPY19L gene family evolution in multiple animal species. An alignment of 42 protein sequences was created in ClustalW and input into MEGA3. The neighbour-joining tree was created using the Jones-Taylor-Thornton matrix for amino acid evolution and bootstrap values, calculated from 250 replications, are shown at internal nodes. Proteins are labeled by species and grouped into families (defined by brackets with family name on the right).