Generating a gene co-expression network. (A) Illustration to show how genes that are highly correlated (blue) will look across a dataset. (B-C) Flow chart for defining a gene co-expression network based on a simple Pearson correlation matrix. (D) An example visualization of a network produced by using the Fruchterman Rheingold algorithm on the data in Figure 1B and 1C. The node highlighted in yellow, is an example of the kind of highly connected node that this study shows is more likely to be an essential gene for survival.
Carlson et al. BMC Genomics 2006 7:40 doi:10.1186/1471-2164-7-40