Table 3 |
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Elevated expression of ORFs associated with single- and double-strand damage caused by exposure of S. cerevisiae to γ-radiation and enediynesa |
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Elevated Expression of ORFS Associated with Single-Strand Damage |
Elevated Expression of ORFS Associated with Double-Strand Damage |
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ORF |
Gene Name |
Description |
ORF |
Gene Name |
Description |
|
|
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|
YLR164W |
--- |
YLR164Wp is homologous to TIM18p |
YNL300W |
--- |
Hypothetical ORF |
|
YPR015C |
--- |
Hypothetical ORF |
YGL101W |
--- |
Hypothetical ORF |
|
YHL035C |
--- |
ABC transporter |
YLR054C |
--- |
Non-essential protein required for construction of the outer spore wall layers |
|
YLR326W |
--- |
Hypothetical ORF |
YLR290C |
--- |
Hypothetical ORF |
|
YDL152W |
--- |
--- |
YER185W |
--- |
Hypothetical ORF |
|
YIR036C |
--- |
Hypothetical ORF |
YNL141W |
AAH1 |
adenine aminohydrolase (adenine deaminase) |
|
YCL033C |
--- |
Hypothetical ORF |
YBR158W |
AMN1 |
Involved in daughter cell separation and Chromosome STability |
|
YLR077W |
--- |
The authentic, non-tagged protein was localized to the mitochondria |
YHR208W |
BAT1 |
branched-chain amino acid transaminase |
|
YBR070C* |
--- |
Protein required for cell viability |
YHR052W |
CIC1 |
Core interacting component 1 |
|
YLR109W |
AHP1 |
alkyl hydroperoxide reductase |
YPL256C |
CLN2 |
G1 cyclin |
|
YJL115W |
ASF1 |
anti-silencing protein |
YNL112W |
DBP2 |
ATP dependent RNA helicase|dead box protein |
|
YML102W |
CAC2 |
chromatin assembly factor-I (CAF-I) p60 subunit |
YDL160C |
DHH1 |
Cytoplasmic DExD/H-box helicase |
|
YOR031W |
CRS5 |
metallothionein-like protein |
YJL157C |
FAR1 |
Cdc28p kinase inhibitor |
|
YDL101C* |
DUN1 |
protein kinase |
YIL131C |
FKH1 |
forkhead protein |
|
YDL018C |
ERP3 |
p24 protein involved in membrane trafficking |
YBR010W |
HHT2 |
histone H3 (HHT1 and HHT2 code for identical proteins) |
|
YIR038C |
GTT1 |
glutathione transferase |
YER110C |
KAP123 |
karyopherin beta 4 |
|
YBR072W |
HSP26 |
heat shock protein 26 |
YOL025W |
LAG2 |
affects longevity |
|
YIR037W |
HYR1 |
glutathione-peroxidase (putative) |
YDR234W |
LYS4 |
homoaconitase |
|
YOR328W |
PDR10 |
ABC transporter (putative)|highly similar to Pdr5p |
YIL106W |
MOB1 |
Mps One Binder |
|
YNL102W |
POL1 |
DNA polymerase I alpha subunit p180 |
YDR033W |
MRH1 |
Protein that localizes primarily to the plasma membrane |
|
YER095W* |
RAD51 |
Rad51p colocalizes to ~65 spots with Dmc1p prior to synapsis |
YBR093C |
PHO5 |
acid phosphatase |
|
YNL312W |
RFA2 |
29% identical to the human p34 subunit of RF-A|replication factor RF-A subunit 2 |
YGL028C |
SCW11 |
glucanase |
|
YJL026W* |
RNR2 |
ribonucleotide reductase subunit |
YGR245C |
SDA1 |
Severe Depolymerization of Actin |
|
YGL103W |
RPL28 |
ribosomal protein L28 (L29) (rp44) (YL24) |
YIL162W |
SUC2 |
invertase (sucrose hydrolyzing enzyme) |
|
YGR027C |
RPS25A |
ribosomal protein S25A (S31A) (rp45) (YS23) |
YDR297W |
SUR2 |
sphingosine hydroxylase |
|
YER096W |
SHC1 |
Sporulation-specific activator |
YPR016C |
TIF6 |
similar to human translation initiation factor 6 (eIF6); |
|
YDR120C |
TRM1 |
N2,N2-dimethylguanosine-specific tRNA methyltransferase |
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|
YBL004W |
UTP20 |
U3 snoRNP protein |
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|
YBR104W |
YMC2 |
Putative mitochondrial inner membrane transporter |
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|
|
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|
a WT S. cerevisiae was exposed to enediynes or γ-radiation and regression analysis identified genes with increased transcriptional activation associated either with single-strand (left) or double-strand damage (right). Members of the DNA damage signature are highlighted in grey and denoted with an asterisk (*). |
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|
Fry et al. BMC Genomics 2006 7:313 doi:10.1186/1471-2164-7-313 |
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