Table 2

Genes 1–50 of the 180-gene signature of EGFR TKI sensitivity

Probeset

Gene

Description

p-value


205891_at

ADORA2B

adenosine A2b receptor

1.65347E-12

213434_at

EPIM

epimorphin

2.03526E-12

211475_s_at

BAG1

BCL2-associated athanogene

1.2089E-11

201716_at

SNX1

sorting nexin 1

1.3942E-11

219933_at

GLRX2

glutaredoxin 2

2.82157E-11

204513_s_at

ELMO1

engulfment and cell motility 1

2.92588E-11

203011_at

IMPA1

inositol(myo)-1(or 4)-monophosphatase 1

4.20475E-11

202743_at

PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)

4.51605E-11

204491_at

PDE4D

Phosphodiesterase 4D, cAMP-specific

8.05036E-11

204000_at

GNB5

guanine nucleotide binding protein (G protein), beta 5

8.7681E-11

204115_at

GNG11

guanine nucleotide binding protein (G protein), gamma 11

1.02678E-10

218913_s_at

GMIP

GEM interacting protein

2.64411E-10

200994_at

IPO7

importin 7

2.65447E-10

202286_s_at

TACSTD2

tumor-associated calcium signal transducer 2

2.75325E-10

209035_at

MDK

midkine (neurite growth-promoting factor 2)

7.31553E-10

218995_s_at

EDN1

endothelin 1

7.75626E-10

219855_at

NUDT11

nudix (nucleoside diphosphate linked moiety X)-type motif 11

8.77697E-10

209678_s_at

PRKCI

protein kinase C, iota

1.04253E-09

202501_at

MAPRE2

microtubule-associated protein, RP/EB family, member 2

2.31343E-09

212117_at

RHOQ

ras homolog gene family, member Q

3.22134E-09

206277_at

P2RY2

purinergic receptor P2Y, G-protein coupled, 2

3.92313E-09

209295_at

TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

4.33798E-09

205376_at

INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

4.50987E-09

206722_s_at

EDG4

endothelial differentiation, lysophosphatidic acid GPCR,4

7.96715E-09

205673_s_at

ASB9

ankyrin repeat and SOCS box-containing 9

1.24878E-08

201471_s_at

SQSTM1

sequestosome 1

1.34231E-08

204352_at

TRAF5

TNF receptor-associated factor 5

1.46887E-08

206907_at

TNFSF9

tumor necrosis factor (ligand) superfamily, member 9

1.57771E-08

218150_at

ARL5

ADP-ribosylation factor-like 5

2.04888E-08

205459_s_at

NPAS2

neuronal PAS domain protein 2

2.22961E-08

205455_at

MST1R

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

2.45512E-08

202641_at

ARL3

ADP-ribosylation factor-like 3

2.78193E-08

201667_at

GJA1

gap junction protein, alpha 1, 43kDa (connexin 43)

2.86113E-08

210512_s_at

VEGF

vascular endothelial growth factor

2.90316E-08

212104_s_at

RBM9

RNA binding motif protein 9

5.42805E-08

200762_at

DPYSL2

dihydropyrimidinase-like 2

5.43168E-08

221235_s_at

TGFBRAP1

transforming growth factor, beta receptor associated protein 1

5.51367E-08

211302_s_at

PDE4B

phosphodiesterase 4B, cAMP-specific

5.51731E-08

205080_at

RARB

retinoic acid receptor, beta

7.03586E-08

202266_at

TTRAP

TRAF and TNF receptor associated protein

7.2889E-08

205240_at

GPSM2

G-protein signalling modulator 2 (AGS3-like, C. elegans)

8.30858E-08

213798_s_at

CAP1

CAP, adenylate cyclase-associated protein 1 (yeast)

8.61121E-08

221819_at

RAB35

RAB35, member RAS oncogene family

8.9216E-08

207011_s_at

PTK7

PTK7 protein tyrosine kinase 7

9.78716E-08

204255_s_at

VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

1.1087E-07

208864_s_at

TXN

thioredoxin

1.34274E-07

209885_at

RHOD

ras homolog gene family, member D

1.50021E-07

201923_at

PRDX4

peroxiredoxin 4

1.6148E-07

204392_at

CAMK1

calcium/calmodulin-dependent protein kinase I

2.24378E-07

203269_at

NSMAF

neutral sphingomyelinase (N-SMase) activation associated factor

2.59238E-07


* Genes 51–180 are included [see 3]

Balko et al. BMC Genomics 2006 7:289   doi:10.1186/1471-2164-7-289

Open Data