Table 1

Characterization of cell lines used in training and validation





Affymetrix U133A chips







Cell Line
 Type
 Sensitivity to EGFR TKI
 K-Ras Status
 (n) in training
 (n) in validation
 EGFR Status
Training
 A549
 AC
 No
 Mutant (Codon 12)
 8
 N/A
 Wt 1

UKY-29
 AC
 No
 Mutant (Codon 61)1
 3
 N/A
 Wt 1

H1650
 AC
 Yes
 Wt
 6
 N/A
 Mutant (DelE746-A750)1

PC-9
 AC
 Yes
 Wt
 5
 N/A
 Mutant (DelE746-A750)1

H3255
 AC
 Yes
 Wt
 3
 N/A
 Mutant (L858R) 1
Validation
 H358
 AC
 Yes
 Mutant (Codon 12)
 0
 1
 Wt1

H460
 Large Cell
 No
 Mutant (Codon 61)
 0
 1
 Wt1

H1975
 AC
 No
 Wt
 0
 1
 Mutant (L858R, T790M) 1

K562
 CML
 No
 Wt
 0
 1
 Wt1

A431
 Epidermoid
 Yes
 Wt
 0
 1
 Wt (Amplified)1

1 Assayed in this study

AC: Adenocarcinoma

CML: Chronic Myelogenous Leukemia

Balko et al. BMC Genomics 2006 7:289   doi:10.1186/1471-2164-7-289