Table 1

Characterization of cell lines used in training and validation

Affymetrix U133A chips


Cell Line

Type

Sensitivity to EGFR TKI

K-Ras Status

(n) in training

(n) in validation

EGFR Status


Training

A549

AC

No

Mutant (Codon 12)

8

N/A

Wt 1

UKY-29

AC

No

Mutant (Codon 61)1

3

N/A

Wt 1

H1650

AC

Yes

Wt

6

N/A

Mutant (DelE746-A750)1

PC-9

AC

Yes

Wt

5

N/A

Mutant (DelE746-A750)1

H3255

AC

Yes

Wt

3

N/A

Mutant (L858R) 1


Validation

H358

AC

Yes

Mutant (Codon 12)

0

1

Wt1

H460

Large Cell

No

Mutant (Codon 61)

0

1

Wt1

H1975

AC

No

Wt

0

1

Mutant (L858R, T790M) 1

K562

CML

No

Wt

0

1

Wt1

A431

Epidermoid

Yes

Wt

0

1

Wt (Amplified)1


1 Assayed in this study

AC: Adenocarcinoma

CML: Chronic Myelogenous Leukemia

Balko et al. BMC Genomics 2006 7:289   doi:10.1186/1471-2164-7-289

Open Data