|
ToxArray™ data normalized without EC: Overall adjusted p after exposure to PB and fold changes (relative to Control) and pairwise p-values at each dose for each gene (probe) that showed differential expression. Bold text indicates genes identified as differential overall (p < 0.05) in the EC-normalized analysis (Table 1). |
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| Control versus 100 mg/kg |
Control versus 10 mg/kg |
Control versus 1 mg/kg |
James-Stein F-Test |
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| Gene (probe) Name |
Full name |
GenBank |
Fold change |
Pairwise P-value |
Fold change |
Pairwise P-value |
Fold change |
Pairwise P-value |
Overall P-value |
|
|
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| Cyp2b9* |
cytochrome P450, 2b9, phenobarbitol inducible, type a, |
NM_010000 |
8.55 |
0.0000 |
3.56 |
0.0000 |
1.15 |
0.8412 |
0.0000 |
| Cyp2b10 |
Cytochrome P450, 2b10, phenobarbitol inducible, type b |
NM_009998 |
3.93 |
0.0000 |
2.92 |
0.0000 |
-1.08 |
0.8501 |
0.0000 |
| Gdf15 |
growth differentiation factor 15 |
NM_011819 |
2.57 |
0.0000 |
1.26 |
0.6381 |
1.11 |
0.8311 |
0.0002 |
| Gsta2 |
Glutathione S-transferase, alpha 2 (Yc2) |
NM_008182 |
2.26 |
0.0353 |
1.08 |
0.9165 |
-1.22 |
0.7337 |
0.0160 |
| Gstm3 |
glutathione S- transferase mu 3 (EC 2.5.1.18) |
J03953 |
2.21 |
0.0000 |
-1.01 |
0.9793 |
1.31 |
0.4323 |
0.0002 |
| Gadd45b |
growth arrest and DNA-damage-inducible 45 beta |
NM_008655 |
1.93 |
0.0000 |
1.04 |
0.8931 |
-1.12 |
0.6016 |
0.0000 |
| Lpin1 |
lipin 1, alias fatty liver dystrophy |
NM_015763 |
-1.66 |
0.0037 |
-1.02 |
0.9469 |
1.03 |
0.9303 |
0.0051 |
| Gadd45a |
growth arrest and DNA damage inducible |
NM_007836 |
1.62 |
0.0024 |
1.25 |
0.4642 |
-1.22 |
0.4506 |
0.0000 |
| Idi1 |
isopentenyl-diphosphate delta isomerase |
NM_145360 |
-1.57 |
0.0131 |
-1.44 |
0.2098 |
-1.04 |
0.9206 |
0.0160 |
| Por |
NADPH cytochrome p450 oxidoreductase |
NM_008898 |
1.55 |
0.0489 |
1.34 |
0.4157 |
1.07 |
0.8477 |
0.0341 |
| Rbp1 |
retinol binding protein 1, cellular |
NM_011254 |
1.49 |
0.0029 |
1.04 |
0.8850 |
1.14 |
0.5150 |
0.0094 |
| AhR |
rat Ah receptor |
NM_013464 |
1.42 |
0.0676 |
1.06 |
0.8713 |
-1.07 |
0.8304 |
0.0436 |
| Dusp6 |
dual specificity phosphatase 6 |
NM_026268 |
1.41 |
0.0486 |
1.29 |
0.3460 |
-1.04 |
0.9018 |
0.0107 |
| Gsta4 |
Glutathione S-transferase, alpha 4 |
NM_010357 |
1.41 |
0.0037 |
-1.00 |
0.9961 |
-1.09 |
0.6389 |
0.0006 |
| gstm2 |
glutathione S-transferase, mu 2 |
NM_008183 |
1.40 |
0.0131 |
1.05 |
0.8594 |
1.07 |
0.7447 |
0.0329 |
| Ephx1 |
epoxide hydrolase 1, microsomal; Eph1, Eph-1, AI195553 |
NM_010145 |
1.39 |
0.0004 |
1.08 |
0.6873 |
1.11 |
0.4882 |
0.0021 |
| Chk |
choline kinase |
NM_013490 |
-1.39 |
0.0214 |
-1.17 |
0.5202 |
1.03 |
0.9165 |
0.0223 |
| Ugt1a6 |
UDP glycosyltransferase 1 family, polypeptide A6 |
XM_135531 |
1.38 |
0.0019 |
1.22 |
0.2979 |
1.13 |
0.4624 |
0.0063 |
| Lbp |
Lipopolysaccharide binding protein |
NM_008489 |
1.38 |
0.0254 |
1.12 |
0.6547 |
1.35 |
0.1677 |
0.0436 |
| Adcy6 |
adenylate cyclase 6 |
NM_007405 |
-1.34 |
0.0037 |
-1.04 |
0.8511 |
1.01 |
0.9774 |
0.0068 |
| Pitpn |
phosphatidylinositol transfer protein |
NM_008850 |
1.23 |
0.0000 |
1.07 |
0.4947 |
1.08 |
0.4311 |
0.0004 |
| Olfr447 |
olfactory receptor 447 |
NM_146988 |
-1.20 |
0.6328 |
-1.19 |
0.4947 |
1.03 |
0.9112 |
0.0436 |
| Anpep |
aminopeptidase N |
NM_008486 |
1.20 |
0.3851 |
-1.14 |
0.5202 |
-1.02 |
0.9253 |
0.0223 |
| cd8b |
CD8 antigen, beta chain |
NM_009858 |
-1.16 |
0.0158 |
-1.07 |
0.5160 |
-1.11 |
0.2616 |
0.0436 |
| Cyp2a4 |
Cytochrome P450, 2a4 (phenobarbitol inducer |
NM_009997 |
1.14 |
0.3851 |
-1.07 |
0.6474 |
-1.09 |
0.4999 |
0.0045 |
| Mmp9: |
matrix metalloproteinase 9 |
NM_013599 |
-1.14 |
0.0735 |
-1.15 |
0.1425 |
-1.16 |
0.1632 |
0.0305 |
| Egfr |
epidermal growth factor receptor |
NM_007912 |
-1.13 |
0.9847 |
1.07 |
0.8206 |
1.30 |
0.1971 |
0.0192 |
| Hao1 |
hydroxyacid oxidase |
NM_010403 |
-1.12 |
0.9867 |
1.24 |
0.5202 |
1.42 |
0.1991 |
0.0233 |
| Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
NM_008149 |
-1.10 |
0.9847 |
1.11 |
0.5202 |
1.20 |
0.1971 |
0.0063 |
| Ape2 |
AP endonuclease 2 |
NM_029943 |
-1.09 |
0.9867 |
-1.18 |
0.5833 |
-1.43 |
0.1677 |
0.0395 |
| Acadvl |
acyl-Coenzyme A dehydrogenase, very long chain |
NM_017366 |
-1.07 |
0.9867 |
1.10 |
0.5887 |
1.18 |
0.2294 |
0.0436 |
| SCADfamilyprotein |
mRNA for SCAD family protein |
AJ296079 |
-1.05 |
0.9890 |
1.02 |
0.9388 |
1.26 |
0.1971 |
0.0395 |
| PERP |
PERP, TP53 apoptosis effector |
NM_022032 |
-1.04 |
0.9890 |
1.06 |
0.7161 |
1.15 |
0.2892 |
0.0170 |
| Acaa2 |
acetyl-Coenzyme A acyltransferase 2, mitochondrial |
NM_177470 |
-1.02 |
0.9984 |
1.11 |
0.5202 |
1.24 |
0.1632 |
0.0094 |
| Vegfb(2) |
vascular endothelial growth factor B |
NM_011697 |
-1.02 |
0.9984 |
-1.25 |
0.2731 |
-1.31 |
0.1677 |
0.0101 |
| Fads2 |
fatty acid desaturase 2 |
NM_019699 |
-1.02 |
0.9984 |
1.22 |
0.3816 |
1.29 |
0.1902 |
0.0395 |
| Nme2 |
expressed in non-metastatic cells 2, protein |
NM_008705 |
1.01 |
0.9984 |
-1.21 |
0.4947 |
-1.14 |
0.5423 |
0.0436 |
| Pxmp3 |
peroxisomal membrane protein 3 |
NM_008994 |
-1.01 |
0.9984 |
1.11 |
0.3446 |
1.14 |
0.1677 |
0.0242 |
| Unc5h3 |
Unc5c:unc-5 homolog C (C. elegans), rostral cerebellar malform. |
NM_009472 |
-1.00 |
0.9984 |
-1.08 |
0.6381 |
1.03 |
0.8466 |
0.0475 |
|
* Bolded text indicates genes also identified as differential in the EC-normalized analysis (Table 1) | |||||||||
Yauk et al. BMC Genomics 2006 7:266 doi:10.1186/1471-2164-7-266 |
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