|
Biological processes significantly affected (Fisher exact test p value < 0.05) by BaP in MCF-7 cells as determined by EASE |
|||
| MCF-7 time and concentration down-regulated genes |
MCF-7 time and concentration up-regulated genes |
||
|
|
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| Biological Process |
Probability |
Biological Process |
Probability |
| regulation of actin filament length |
4.9E-06 |
water-soluble vitamin metabolism |
3.7E-03 |
| actin cytoskeleton organization and biogenesis |
1.8E-04 |
sodium\:calcium exchange |
6.2E-03 |
| actin filament-based process |
2.4E-04 |
pentose-phosphate shunt, oxidative branch |
6.2E-03 |
| regulation of actin polymerization and/or depolymerization |
4.0E-04 |
glyoxylate cycle |
6.2E-03 |
| one-carbon compound metabolism |
4.6E-04 |
glyoxylate metabolism |
6.2E-03 |
| cell organization and biogenesis |
8.2E-04 |
vitamin metabolism |
8.6E-03 |
| nucleosome assembly |
9.0E-04 |
amino acid transport |
1.2E-02 |
| carboxylic acid metabolism |
1.5E-03 |
thiamin and derivative metabolism |
1.2E-02 |
| organic acid metabolism |
1.6E-03 |
embryonic eye morphogenesis |
1.2E-02 |
| actin polymerization and/or depolymerization |
2.2E-03 |
solute, solute exchange |
1.2E-02 |
| amine metabolism |
2.4E-03 |
thiamin metabolism |
1.2E-02 |
| establishment and/or maintenance of chromatin architecture |
3.2E-03 |
internal protein amino acid acetylation |
1.2E-02 |
| DNA packaging |
4.3E-03 |
eye morphogenesis (sensu Vertebrata) |
1.2E-02 |
| chromatin assembly/disassembly |
4.7E-03 |
eye morphogenesis (sensu Mammalia) |
1.2E-02 |
| amino acid metabolism |
4.7E-03 |
isocitrate metabolism |
1.2E-02 |
| cytoskeleton organization and biogenesis |
5.8E-03 |
amine/polyamine transport |
1.3E-02 |
| chromosome organization and biogenesis (sensu Eukarya) |
6.4E-03 |
regulation of CDK activity |
1.4E-02 |
| muscle maintenance |
6.5E-03 |
negative regulation of cell proliferation |
1.6E-02 |
| negative regulation of actin filament polymerization |
6.5E-03 |
GPI anchor biosynthesis |
1.8E-02 |
| anion homeostasis |
6.5E-03 |
GPI anchor metabolism |
1.8E-02 |
| monovalent inorganic anion homeostasis |
6.5E-03 |
regulation of survival gene product activity |
1.8E-02 |
| asparagine metabolism |
6.5E-03 |
negative regulation of survival gene product activity |
1.8E-02 |
| sequestering of actin monomers |
6.5E-03 |
G2/M transition of mitotic cell cycle |
1.9E-02 |
| asparagine biosynthesis |
6.5E-03 |
carboxylic acid transport |
2.1E-02 |
| nuclear organization and biogenesis |
6.8E-03 |
organic acid transport |
2.1E-02 |
| amino acid and derivative metabolism |
7.8E-03 |
apoptotic mitochondrial changes |
2.4E-02 |
| cell growth |
1.0E-02 |
germ-cell development |
2.4E-02 |
| myelination |
1.3E-02 |
protein amino acid acetylation |
2.4E-02 |
| isoleucyl-tRNA aminoacylation |
1.3E-02 |
G1/S transition of mitotic cell cycle |
2.5E-02 |
| threonyl-tRNA aminoacylation |
1.3E-02 |
NADPH metabolism |
3.0E-02 |
| regulation of actin filament polymerization |
1.3E-02 |
NADPH regeneration |
3.0E-02 |
| organelle organization and biogenesis |
1.7E-02 |
CTP biosynthesis |
3.0E-02 |
| salivary gland morphogenesis |
1.9E-02 |
UTP metabolism |
3.0E-02 |
| salivary gland development |
1.9E-02 |
UTP biosynthesis |
3.0E-02 |
| folic acid and derivative biosynthesis |
2.6E-02 |
pentose-phosphate shunt |
3.0E-02 |
| glycine metabolism |
2.6E-02 |
CTP metabolism |
3.0E-02 |
| cytoplasm organization and biogenesis |
2.6E-02 |
synaptic transmission\, cholinergic |
3.0E-02 |
| actin filament polymerization |
3.2E-02 |
eye morphogenesis |
3.0E-02 |
| folic acid and derivative metabolism |
3.2E-02 |
pyrimidine ribonucleoside triphosphate metabolism |
3.0E-02 |
| regulation of cell growth |
3.8E-02 |
pyrimidine ribonucleoside triphosphate biosynthesis |
3.0E-02 |
| aspartate family amino acid biosynthesis |
3.8E-02 |
pyrimidine ribonucleotide biosynthesis |
3.6E-02 |
| L-serine metabolism |
3.8E-02 |
GTP metabolism |
3.6E-02 |
| nerve ensheathment |
4.4E-02 |
GTP biosynthesis |
3.6E-02 |
| negative regulation of cell adhesion |
4.4E-02 |
pyrimidine ribonucleotide metabolism |
3.6E-02 |
| nerve maturation |
4.4E-02 |
nicotinamide metabolism |
3.6E-02 |
| glycosphingolipid biosynthesis |
4.4E-02 |
pyrimidine nucleoside triphosphate metabolism |
3.6E-02 |
| tRNA aminoacylation for protein translation |
4.6E-02 |
phosphoinositide biosynthesis |
3.6E-02 |
| tRNA aminoacylation |
4.6E-02 |
oncogenesis |
3.8E-02 |
| amino acid activation |
4.6E-02 |
DNA repair |
4.2E-02 |
| tRNA modification |
4.7E-02 |
covalent chromatin modification |
4.2E-02 |
| phosphoinositide metabolism |
4.2E-02 |
||
| histone deacetylation |
4.2E-02 |
||
| pyridine nucleotide metabolism |
4.2E-02 |
||
| heavy metal sensitivity/resistance |
4.2E-02 |
||
| nerve-nerve synaptic transmission |
4.2E-02 |
||
| histone modification |
4.2E-02 |
||
| aldehyde metabolism |
4.2E-02 |
||
| protein modification |
4.3E-02 |
||
| main pathways of carbohydrate metabolism |
4.5E-02 |
||
| obsolete biological process |
4.7E-02 |
||
| prostanoid metabolism |
4.8E-02 |
||
| embryonic development (sensu Vertebrata) |
4.8E-02 |
||
| lipoprotein biosynthesis |
4.8E-02 |
||
| insulin receptor signaling pathway |
4.8E-02 |
||
| prostaglandin metabolism |
4.8E-02 |
||
| embryonic development (sensu Mammalia) |
4.8E-02 |
||
| protein lipidation |
4.8E-02 |
||
Hockley et al. BMC Genomics 2006 7:260 doi:10.1186/1471-2164-7-260 |
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