Table 3

Overview of representative hits above 0.8

Lab/Condition
Cog/Protein Name
Correlation
P-value
Protein Function

B01/Gram-negative
COG0763/Lipid A
disaccharide synthetase
0.95
1.71E-09
Involved in Lipid A biosynthesis [26–28]

COG0774/UDP-3-O-acyl-N-acetylglucosamine
deacetylase
0.95
1.71E-09
Involved in Lipid A biosynthesis [29] [27,30]

COG1212/CMP-2-keto-3-deoxyoctulosonic
acid synthetase
0.95
1.71E-09
Involved in lipopolysaccharide biosynthesis [31]

COG2877/3-deoxy-D-manno-octulosonic acid
(KDO) 8-phosphate synthase
0.95
1.71E-09
Involved in lipopolysaccharide biosynthesis [32]

COG0848/Biopolymer
transport protein
0.95
1.71E-09
Outer membrane transporters [33,34]

COG2885/Outer membrane
protein
0.84
2.46E-09
Outer membrane protein [35]
B02/Gram-positive
COG3764/Sortase
1.0
2.59E-08
Plasma membrane protein [36]

COG2344/AT-rich DNA-binding
protein
0.92
7.77E-07
Transcriptional regulator [37]

COG3966/Protein involved in D-alanine
esterification of lipoteichoic acid and wall
teichoic acid (D-alanine transfer protein)
0.84
1.2E-05
Cell wall and membrane component protein [38]
B29/Growth on MacConkey Agar
COG4206/Outer membrane
cobalamin receptor protein
0.99
8.04E-09
Outer membrane protein [39]

COG4787/Flagellar basal body
rod protein
0.97
2.33E-07
Periplasmic protein [40]

COG3166/Tfp pilus assembly
protein PilN
0.83
9.77E-06
Outer membrane proteins [41]
B30/Oxidase
COG3278/Cbb3-type cytochrome oxidase,
subunit 1
0.85
7.84E-06
Oxidase protein subunit
B30/Oxidase
COG2993/Cbb3-type cytochrome oxidase,
cytochrome c subunit
0.85
7.84E-06
Oxidase protein subunit
B31/Catalase
COG0753/Catalase
0.97
7.69E-06
Peroxisomal Marker Enzyme

COG1607/Acyl-CoA hydrolase
0.97
7.69E-06
Enzyme involved in lipid metabolism [13]
FAC/L-Arabinose
COG3717/5-keto 4-deoxyuronate isomerase
0.97
3.95E-05
Enzyme involved in carbohydrate metabolism [14,15]
FAM/D-Mannose
COG0246/Mannitol-1-phosphate/altronate
dehydrogenases
0.85
4.68E-05
Oxidizes mannitol to mannose [42]
FAT/Trehalose
COG2182/Maltose-binding periplasmic
proteins/domains
0.94
3.4E-05
Maltose-related protein [16]
G03/Motile
COG0835/Chemotaxis signal
transduction protein
0.94
4.93E-09
Chemotaxis-related protein

COG1345/Flagellar capping protein
0.94
4.93E-09
Flagella-related protein

COG1516/Flagellin-specific chaperone FliS
0.94
4.93E-09
Flagella-related protein

Goh et al. BMC Genomics 2006 7:257   doi:10.1186/1471-2164-7-257