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Open Access Research article

Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates

Xuming Xu1, Samuel Shao-Min Zhang12, Colin J Barnstable12 and Joyce Tombran-Tink12*

Author Affiliations

1 Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA

2 Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA

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BMC Genomics 2006, 7:248  doi:10.1186/1471-2164-7-248

Published: 4 October 2006

Additional files

Additional File 1:

Phylogenetic relationship of PEDF to other serpins. A total of 88 serpins with 14 PEDF sequences were used to construct this bootstrap consensus tree based on 500 replicates. The numbers on nodes are bootstrap values.

Format: XLS Size: 85KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional File 2:

Intron-Exon junction sequences of the PEDF gene for human, mouse, chick, western clawed frog, zebrafish, and fugu. Intron sequences shown in lower case and exon sequences in upper case.

Format: DOC Size: 28KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional File 3:

List of PCR primers for PEDF RT-PCR analysis from each species.

Format: DOC Size: 26KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data