Table 3

Trends in amino acid replacements in N. equitans proteins and their mesophilic orthologs

N. equitans amino acid


Arg

Lys

Glu

Asp

Trp

Ile

Pro

Leu

Val

Phe

Tyr

Met

His

Ala

Gly

Cys

Thr

Asn

Gln

Ser


Mesophilic homologs amino acid

Ser

1.34

2.83*

2.47*

2.02

-

3.07*

2.65

2.30

2.43

3.33

2.55

2.44

0.81

1.35

1.13

0.14+

1.04

1.57

1.64

1.00

Gln

1.52

1.56*

1.03

0.75

1.50

3.86*

2.18

2.13

0.74

1.00

2.60

1.21

1.20

0.72

0.55

0.00

0.29+

1.17

1.00

Asn

1.02

1.67*

0.87

0.96

2.00

1.71

0.91

1.14

0.65

0.54

3.00*

2.00

1.13

0.54

0.78

0.67

0.77

1.00

Thr

1.33

2.38*

1.91

1.00

4.00

2.23*

2.35

2.72*

1.47

1.45

5.00*

0.76

1.50

1.11

1.04

0.50

1.00

Cys

-

-

1.50

5.00

1.00

3.00

-

7.00

7.50*

4.00

11.00

-

-

7.33*

6.00

1.00

Gly

1.61

2.10*

1.27

1.06

-

6.00*

2.60*

2.06

2.09

2.00

5.00*

1.57

2.00

1.18

1.00

Ala

2.05*

2.89*

2.76*

1.94

8.00

1.59

1.59

1.83*

1.14

2.06

5.00*

1.18

1.63

1.00

His

1.57

1.89

0.86

1.15

4.00

4.33

1.20

1.70

0.91

2.29

3.44*

1.67

1.00

Met

1.73

1.76

1.31

2.33

3.00

2.20*

1.00

2.28*

1.55

1.81

2.50

1.00

Tyr

0.35

0.55

0.47

0.33

1.07

0.75

0.52

0.65

0.30+

0.87

1.00

Phe

0.53

0.88

1.12

0.42

1.48

1.04

0.58

0.94

0.70

1.00

Val

1.15

2.05*

0.80

1.00

4.50

1.57*

0.94

1.44*

1.00

Leu

0.62

1.35*

1.04

0.61

1.80

1.32*

1.03

1.00

Pro

1.00

1.05

0.62

0.86

1.50

1.08

1.00

Ile

0.66

0.84

0.76

0.53

3.25*

1.00

Trp

0.38

1.00

0.50

1.50

1.00

Asp

2.21

1.74*

1.21

1.00

Glu

0.97

1.61*

1.00

Lys

0.91

1.00

Arg

1.00


Each cell in the table is the ratio of replacements for a particular pair of amino acid. * indicates the replacements favored in the mesophilic to thermophilic direction whereas + indicates the opposite direction of such replacements have significant directional bias (P < 0.01).

Das et al. BMC Genomics 2006 7:186   doi:10.1186/1471-2164-7-186

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